Maternal and foetal consequences of dengue fever during pregnancy
Maternal and foetal consequences of dengue fever during pregnancy
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DOI：
10.1016/j.ejogrb.2009.06.028
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发表时间：
2009-11-01
影响因子：
2.6
通讯作者：
Guindi, Wael E. L.
中科院分区：
文献类型：
--
作者：
Basurko, Celia;Carles, Gabriel;Guindi, Wael E. L.
目的：探讨妊娠期登革热感染对母婴的影响。研究设计：对1992年1月1日至2006年9月10日53名孕期感染登革热的孕妇进行回顾性研究。这些妇女是圣洛朗·杜·马罗尼医院妇产科的病人。登革热感染是通过存在特定的IgM或通过病毒分离(聚合酶链式反应或培养)确认的。收集的数据涉及怀孕期间和出生时的产科和胎儿后果，以及对新生儿的影响。母婴传播的风险是从出生时从脐带取血的20个样本进行评估的。结果：主要孕产妇结局为：早产(41%)、早产(9.6%)、产中出血(9.3%：5例)、胎盘后血肿(1.9%：1例)；胎儿结局：早产(20%)、胎儿宫内死亡(3.8%：2例)、晚期流产(3.8%：2例)、产中急性胎儿窘迫(7.5%：4例)、母婴传播(5.6%：3例)、新生儿死亡(1.9%：1例)。结论：孕妇在怀孕期间感染登革热病毒是早产的真实风险。当感染发生在近月时，母亲和婴儿也有出血的风险。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Objective: The aim of the study was to assess the maternal and foetal consequences of dengue fever infection during pregnancy.Study design: A retrospective study was carried out from 1 January 1992 to 10 September 2006 on 53 pregnant women infected with the dengue virus during pregnancy. The women were patients of the obstetrics and gynaecology department of Saint Laurent du Maroni hospital. A dengue infection was confirmed either by the presence of specific IgMs or by isolation of the virus (PCR or culture). The data collected related to obstetric and foetal consequences both during pregnancy and at birth, as well as the effect on the newborn.The risk of maternal-foetal transmission was assessed from 20 samples of blood taken from the umbilical cord at birth. Results: The principal maternal consequences were: premature labour (41%), premature birth (9.6%), haemorrhage during labour (9.3%: 5 cases) and retroplacental haematoma (1.9%: 1 case).Foetal consequences were: prematurity (20%), foetal death in utero (3.8%: 2 cases), late miscarriage (3.8%: 2 cases), acute foetal distress during labour (7.5%: 4 cases), maternal-foetal transmission (5.6%: 3 cases) and neonatal death (1.9%: 1 case). Conclusions: Maternal infection with the dengue virus during pregnancy represents a real risk of premature birth.There is also a risk of haemorrhage both for the mother and the baby when infection occurs near term. (C) 2009 Elsevier Ireland Ltd. All rights reserved.