Increased cardiac output increases shunt: role of pulmonary edema and perfusion.
Increased cardiac output increases shunt: role of pulmonary edema and perfusion.
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心输出量增加增加分流：肺水肿和灌注作用。
DOI：
10.1152/jappl.1985.59.4.1313
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Wood,LD
中科院分区：
文献类型：
--
作者：
Breen,PH;Schumacker,PT;Sandoval,J;Mayers,I;Oppenheimer,L;Wood,LD
在低压肺水肿中，心输出量（QT）增加会增加分流（Qs/QT）;我们测试了其机制是否是血管外肺水增加，进而由伴随的微血管压力增加介导。在六个戊巴比妥钠麻醉的狗与O2通气，我们管理油酸进入右心房。从基线到油酸后2小时，我们测量到Qs/QT同时显著增加（6- 29%，O2技术）和血管外热容量（ETV，2.6-7.1 ml/g干血管内无血肺重量，热绿染料指示剂技术）稳定90 min。然后，双侧股动静脉瘘在30分钟内打开和关闭，导致QT和相关Qs/QT可逆性增加。内瘘开放时，平均QT间期从5.1分钟增加到6.9分钟（P <0.05），同时Qs/QT从30.7%增加到38.4%（P <0.05），但ETV没有增加。我们的结论是，肺水肿的增加并不能解释我们的上升Qs/QT时，QT增加。
In low-pressure pulmonary edema increased cardiac output (QT) increases shunt (Qs/QT); we tested whether the mechanism is an increase in extravascular lung water in turn mediated by the accompanying increase in microvascular pressure. In six pentobarbital sodium-anesthetized dogs ventilated with O2 we administered oleic acid into the right atrium. From base line to 2 h post-oleic acid we measured concurrent significant increases in Qs/QT (6–29%, O2 technique) and extravascular thermal volume (ETV, 2.6–7.1 ml/g dry intravascular blood-free lung wt, thermal-green dye indicator technique) that were stable by 90 min. Then, bilateral femoral arteriovenous fistulas were opened and closed in 30-min periods to cause reversible increases in QT and associated Qs/QT. When fistulas were open the time-averaged QT increased from 5.1 to 6.9 min (P less than 0.05), the simultaneous Qs/QT rose from 30.7 to 38.4% (P less than 0.05), but ETV did not increase. We conclude that increasing lung edema does not account for our rise in Qs/QT when QT increased.