Natriuretic and hypertensive activities reside in a fragment of ACTH.
Natriuretic and hypertensive activities reside in a fragment of ACTH.
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DOI：
10.1161/01.hyp.6.4.468
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发表时间：
1984-07
期刊：
影响因子：
8.3
通讯作者：
K. Gruber;M. Klein;P. Hutchins;V. Buckalew;J. Lymangrover
中科院分区：
文献类型：
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作者：
K. Gruber;M. Klein;P. Hutchins;V. Buckalew;J. Lymangrover
慢性肾上腺皮质促激素（ACTH）的降压和利钠作用不能被糖皮质激素和/或矿皮质激素的施用所重复。我们研究了这种激素的片段（ACTH4-10）和类似片段（D-Phe7） ACTH4-10的作用，发现它们在大鼠体内具有加压和加速作用，静脉注射剂量为30至1000 nmol/kg。α受体（酚妥拉明）和β受体（美托洛尔）拮抗剂可减弱（D-Phe7） ACTH4-10的升压和加速作用。ACTH4-10在肾上腺切除或神经节阻滞（用甲胺）大鼠中产生心血管作用。在较低剂量（7 nmol/kg静脉注射）下，ACTH4-10具有利钠作用，其活性模式与较大ACTH片段α -黑色素细胞刺激激素相似。完整ACTH分子的肾上腺外作用或体内ACTH产生的acth4 -10样片段可能与该激素相关的高血压和利钠作用有关。
The hypertensive and natriuretic effects of chronic administration of adrenocorticotrophic hormone (ACTH) cannot be duplicated by the administration of glucocorticoids and/or mineralocorticoids. We investigated the effects of a fragment of this hormone (ACTH4-10) and an analog of the fragment (D-Phe7) ACTH4-10 and found them to have pressor and cardioaccelerator actions in rats as determined by bolus intravenous (i.v.) injections of 30 to 1000 nmol/kg. The pressor and cardioaccelerator effects of (D-Phe7) ACTH4-10 were attenuated by alpha-receptor (phentolamine) and beta-receptor (metoprolol) antagonists. The cardiovascular actions of ACTH4-10 were produced in adrenalectomized or ganglionic-blocked (with mecamylamine) rats. At a lower dose (7 nmol/kg i.v.), ACTH4-10 was natriuretic and had a pattern of activity similar to that of a larger ACTH fragment, alpha-melanocyte-stimulating hormone. Extraadrenal effects of the intact ACTH molecule or the in vivo production of an ACTH4-10-like fragment from ACTH may contribute to the hypertensive and natriuretic actions associated with this hormone.