Olfactory mucosa in nasal polyposis: Implications for FESS outcome
Olfactory mucosa in nasal polyposis: Implications for FESS outcome
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DOI：
10.4193/rhin09.102
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发表时间：
2010-03-01
期刊：
影响因子：
7.2
通讯作者：
Gudziol, Volker
中科院分区：
文献类型：
--
作者：
Konstantinidis, Iordanis;Witt, Martin;Gudziol, Volker
目的：本研究探讨鼻息肉病患者的嗅上皮活检，与嗅觉测试结果和嗅觉功能障碍的评级术前和术后。材料与方法：27例鼻息肉病患者被纳入。嗅觉功能用“嗅棒”测试。在内窥镜手术结束时从嗅区进行活检，并进行免疫组织化学研究。患者使用视觉模拟量表报告他们的嗅觉功能障碍时，重新检查一年postoperatives.Results：受试者很少或没有炎症的嗅觉和呼吸道活检的病程较短，嗅觉功能更好。嗅粘膜的病理改变包括呼吸道上皮化生、上皮变性、上皮表面破裂和炎性细胞浸润。术后嗅觉测试结果显示74%的患者嗅觉改善。虽然这种改善似乎在很少或没有炎症的受试者中更好，但这并不显著。手术前后嗅觉测试结果呈正相关。结论：疾病过程包括结构组织的丧失和炎性浸润的嗅上皮。炎症严重程度与嗅觉测试结果相关，但它不是术后唯一的预测因素。
Objective: This study investigates olfactory epithelium biopsies from patients with nasal polyposis, in correlation with olfactory test results and ratings of olfactory dysfunction pre- and postoperatively.Material & Methods: Twenty-seven patients with nasal polyposis were included. Olfactory function was tested with the "Sniffin Sticks" test. Biopsies from the olfactory region performed at the end of endoscopic surgery and studied with immunohistochemistry. Patients used a visual analogue scale to report their olfactory dysfunction when re-examined one year postoperatively.Results: Subjects with little or no inflammation in olfactory and respiratory biopsies had shorter duration of disease and better olfactory function. Pathological changes of olfactory mucosa included replacement by respiratory metaplasia, degenerated epithelium, rupture of epithelial surface and infiltration by inflammatory cells. Postoperative olfactory test results showed improvement of olfaction in 74% of patients. Although this improvement seemed to be better in subjects with little or no inflammation, this was not significant. Preoperative and postoperative olfactory test results were positively correlated.Conclusions: The disease process includes loss of structural organization and inflammatory infiltration of the olfactory epithelium. The inflammation severity is related to the olfactory test results; however, it cannot be the only predictive factor postoperatively.