Vrk2 deficiency elicits aggressive behavior in female zebrafish
Vrk2 deficiency elicits aggressive behavior in female zebrafish
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DOI：
10.1111/gtc.12924
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发表时间：
2022-02-15
期刊：
影响因子：
2.1
通讯作者：
Hanada，Reiko
中科院分区：
文献类型：
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作者：
Umeda，Ryohei;Teranishi，Hitoshi;Hanada，Reiko
牛痘相关激酶2（VRK 2）是一种丝氨酸/苏氨酸激酶，最初在高度增殖的细胞（如胸腺细胞和胎肝细胞）中发现，参与细胞增殖和存活。VRK 2也在大脑中表达;然而，其在中枢神经系统中的分子功能大多未知。许多全基因组关联研究（GWASs）已经报道，VRK 2是人类精神分裂症等神经精神疾病的潜在候选分子。然而，VRK 2和神经精神疾病之间的病理生理关系尚未得到充分研究。在这项研究中，我们评估了dvrk 2-缺陷（vrk 2-/-）斑马鱼，发现vrk 2-/-雌性斑马鱼与对照（vrk 2 +/+）斑马鱼相比表现出攻击行为和不同的社会偏好，与vrk 2 +/+斑马鱼相比，脑中γ-氨基丁酸（GABA）含量低，神经元树突密度高。这些发现表明，雌性斑马鱼确实是一种以攻击和社会互动为特征的不良行为模型，这可以归因于其大脑中GABA含量低。
Vaccinia‐related kinase 2 (VRK2) is a serine/threonine kinase initially identified in highly proliferative cells such as thymocytes and fetal liver cells, and it is involved in cell proliferation and survival. VRK2 is also expressed in the brain; however, its molecular function in the central nervous system is mostly unknown. Many genome‐wide association studies (GWASs) have reported that VRK2 is a potential candidate molecule for neuropsychiatric diseases such as schizophrenia in humans. However, the pathophysiological relationship between VRK2 and neuropsychiatric disorders has not been fully investigated. In this study, we evaluatedvrk2‐deficient (vrk2−/−) zebrafish and found thatvrk2−/−female zebrafish showed aggressive behavior and different social preference compared with control (vrk2+/+) zebrafish, with low gamma‐aminobutyric acid (GABA) content in the brain and high density of neuronal dendrites when compared tovrk2+/+zebrafish. These findings suggest that femalevrk2−/−zebrafish were indeed a model of malbehavior characterized by aggression and social interaction, which can be attributed to the low levels of GABA content in their brain.