Modeling the relation between neurofibrillary tangles and intellectual status
Modeling the relation between neurofibrillary tangles and intellectual status
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DOI：
10.1016/s0197-4580(97)80306-5
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发表时间：
1997-05-01
影响因子：
4.2
通讯作者：
Hauw, JJ
中科院分区：
文献类型：
--
作者：
Duyckaerts, C;Bennecib, M;Hauw, JJ
研究人员对 27 名 75 岁以上的老年痴呆症患者中观察到的神经原纤维缠结与智力缺陷之间的关系进行了研究。评估了边缘系统、旁边缘系统和等皮质皮质等 6 个区域中 tau 阳性缠结的存在和密度。在等皮质区域，神经原纤维缠结的存在 [1] 或不存在 [0] 与 Blessed 测试分数的相关性比神经原纤维缠结分布的密度更好。多变量分析表明，包含至少一个神经原纤维缠结的区域数量是智力状态的最佳解释变量。皮质区域根据其参与的普遍程度进行排名。只有当较低级别的区域也被涉及时，给定级别的区域中才会出现缠结。有人提出，给定区域中缠结的存在是比其密度值更重要的信息。这些数据可能会导致新的诊断程序。 (C) 1997 爱思唯尔科学公司。
The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied in 27 patients over the age of 75. The presence and density of tau positive tangles were assessed in six areas including limbic, paralimbic, and isocortical cortices. In the isocortical areas, the presence [1] or absence [0] of neurofibrillary tangles was better correlated with the Blessed test score than the density of the neurofibrillary tangles profiles. Multivariate analysis showed that the number of areas containing at least one neurofibrillary tangle was the best explanatory variable of the intellectual status. The cortical areas were ranked according to the prevalence of their involvement The presence of tangles in an area of a given rank took place only if the areas of lower ranks were also involved. It is proposed that the presence of tangles in a given area is a more significant information than the value of their density. These data may lead to new diagnostic procedures. (C) 1997 Elsevier Science Inc.