Pd-Catalyzed Diamination of 1,2,4-Triazinyl Complexant Scaffolds.
Pd-Catalyzed Diamination of 1,2,4-Triazinyl Complexant Scaffolds.
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Pd 催化的 1,2,4-三嗪基络合剂支架的二胺化。
DOI：
10.1021/acs.joc.5b00710
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Carrick,JesseD
中科院分区：
文献类型：
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作者：
Tai,Serene;Dover,EvanJ;Marchi,SydneyV;Carrick,JesseD
作为本实验室正在进行的设计和合成多齿软N-供体作为从用过的核燃料中化学选择性地提取次要元素的有效络合剂的努力的一部分，需要一系列胺化的单-1，2，4-三嗪基吡啶。这项研究的重点是利用钯催化从一个常见的合成子获得4，4‘-氨基吡啶三嗪类化合物，这些化合物在商业上是有限的，在传统的缩合化学中是不成功的。提出了一种通用的钯催化双胺化功能化吡啶基-1，2，4-三嗪的方法，催化剂/配体负载量低，可形成16种新型络合剂。
As part of ongoing efforts in this laboratory to design and synthesize multidentate soft-N-donors as effective complexants for chemoselective minor actinide extraction from used nuclear fuel, a series of aminated mono-1,2,4-triazinylpyridines were required. This study focuses on streamlining convergent access to a diverse array of functionalized N-donors using Pd-catalysis from a common synthon affording access to pyridinyl triazines as the 4,4′-amino derivatives which are commercially limited and unsuccessful in traditional condensation chemistry. A general Pd-catalyzed method for the double amination of functionalized pyridinyl-1,2,4-triazines with low catalyst/ligand loadings enabling the formation of 16 novel complexants is presented.