Effect of oral consumption of vitamin D on uterine fibroids: A randomized clinical trial
Effect of oral consumption of vitamin D on uterine fibroids: A randomized clinical trial
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DOI：
10.1016/j.ctcp.2020.101159
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发表时间：
2020-05-01
影响因子：
3
通讯作者：
Kutenaei, Maryam Azizi
中科院分区：
文献类型：
--
作者：
Arjeh, Somayye;Darsareh, Fatemeh;Kutenaei, Maryam Azizi
背景：子宫肌瘤是女性生殖系统常见的肿瘤。有症状的子宫肌瘤需要根据症状的严重程度进行手术或药物治疗。本研究旨在探讨维生素D对子宫肌瘤的影响。 材料和方法：于2018年6月至11月进行了一项随机临床试验。符合条件的女性被随机分配接受维生素Dora安慰剂，为期12周。肌瘤体积的变化被认为是疗效评价的主要变量。结果：实验组肌瘤体积未见统计学显着下降[平均差（MD）：-0.71，95%置信区间（CI）：-0.1至1.53，P=0.085]，而对照组肌瘤体积显着增加（MD：2.53，95% CI： 1.9 至 4.05，p = 0.001）。结论：摄入维生素 D 可能会抑制子宫肌瘤的生长；然而，长期影响仍不清楚。
Background: and purpose: Uterine fibroids are common tumors of the female reproductive system. Symptomatic uterine fibroids require surgical or medical therapy depending on the severity of the symptoms. This study was conducted to investigate the effect of vitamin D on uterine fibroids.Materials and methods: A randomized clinical trial was conducted from June to November 2018. Eligible women were randomly assigned to receive vitamin Dora placebo for 12 weeks. The change in the volume of fibroids was considered to be the main variable in the efficacy evaluation.Results: No statistically significant decrease in the volume of fibroids was observed in the experimental group [mean difference (MD): -0.71, 95% confidence interval (CI): -0.1 to 1.53, P = 0.085], and a significant increase was observed in the size of fibroids in the control group (MD: 2.53, 95% CI: 1.9 to 4.05, p = 0.001).Conclusion: Vitamin D consumption might inhibit growth of uterine fibroids; however, the long-term effects remain unclear.