Large retroperitoneal low-grade extraskeletal osteosarcoma
Large retroperitoneal low-grade extraskeletal osteosarcoma
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腹膜后大型低级别骨外骨肉瘤
DOI：
10.1136/bcr-2014-203745
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发表时间：
2014
期刊：
影响因子：
0.9
通讯作者：
S. Kataria
中科院分区：
文献类型：
--
作者：
J. Jaipuria;Ashok Kumar;A. Rao;S. Kataria
低级别骨外骨肉瘤是一种极为罕见的肿瘤，文献中仅报道了9例，其中只有1例累及腹膜后。去分化的趋势以及复发的高级别变异是已知的，管理原则没有很好地定义，需要不断回顾文献。我们报告了一名38岁男性患者对最大的腹膜后肿瘤（18.0 cmx 18.3 cm×17.8 cm）的治疗，手术治疗后，顺铂（90mg /m2，第1天和第2天）和阿霉素（75mg /m2，第3天）6个周期，每3周一个周期（必要时给予粒细胞集落刺激因子支持）。患者随访3年后无病。
Low-grade extraskeletal osteosarcoma is an extremely rare neoplasm with only nine cases reported in the literature, in which only one case involved the retroperitoneum. Tendency to dedifferentiate as well as recur with high-grade variant is known and management principles are not well defined, necessitating a continuous review of literature. We report management of the largest such retroperitoneal tumour (18.0 cm× 18.3 cm×17.8 cm) in a 38-year-old man, which was treated with surgery followed by six cycles of cisplatin (90 mg/m2 days 1 and 2) and doxorubicin (75 mg/m2 day 3), cycled every 3 weeks (with granulocyte colony stimulating factor support as necessary). The patient is disease free after 3 years of follow-up.