Cranial Computed Tomography (CCT) Findings in Children Treated with ACTH and Dexamethasone: First Results
Cranial Computed Tomography (CCT) Findings in Children Treated with ACTH and Dexamethasone: First Results
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接受 ACTH 和地塞米松治疗的儿童的颅脑计算机断层扫描 (CCT) 结果：初步结果
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
D. Kühne1
中科院分区：
文献类型：
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作者：
I. Lagenstein;R. Willig;D. Kühne1
对8例不同类型的癫痫小发作患儿采用促肾上腺皮质激素（ACTH）和地塞米松进行系统治疗。治疗前、治疗中、治疗后均行CCT检查。在所有儿童严重的大脑变化。脑室和蛛网膜下腔的扩大在Depot-ACTH治疗的初始阶段发展。在此后的地塞米松治疗阶段，也可能出现类似的变化，但严重程度较轻。所有患者的大脑变化消失后激素治疗已经结束。在这一点上，许多儿童有一个发展的冲刺，发展复发无法观察。这表明，这些可逆的变化上看到CCT扫描代表了一种形式的形态可塑性的大脑结构。这些结果对脑水肿的治疗具有一定的指导意义。
8 children with different petit mal epilepsies were systematically treated with ACTH and dexamethasone. CCT examinations were performed before, during and after treatment. In all children severe cerebral changes. enlargement of ventricles and subarachnoid space developed during the initial phase of treatment with Depot-ACTH. Similar changes, but to a less severe degree, could be demonstrated during the phase of dexamethasone therapy thereafter. In all patients cerebral changes disappeared after hormonal treatment had ended. At this point many children had a developmental spurt, developmental relapses could not be observed. It is suggested that these reversible changes seen on CCT scans represent a form of morphological plasticity of brain structures. These results bear certain consequences as to the therapy of cerebral edema.