[Signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus].
[Signal peptide peptidase participates in propagation and pathogenesis of hepatitis C virus].
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DOI：
10.2222/jsv.67.49
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T. Okamoto
中科院分区：
文献类型：
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作者：
T. Okamoto
丙型肝炎病毒（HCV）是一种血液传播的病毒，可引起慢性感染，导致脂肪变性、肝硬化和肝细胞癌。然而，HCV感染诱导肝脏疾病的分子机制尚不清楚。本文就信号肽酶加工HCV核心蛋白在HCV传播和发病中的病毒学意义作一综述。
Hepatitis C virus (HCV) is a blood-borne virus and causes chronic infection leading to development of steatosis, cirrhosis and hepatocellular carcinoma. However, molecular mechanisms of induction of liver diseases by HCV infection are still unclear. This review focuses on thevirological significance of processing of HCV core protein by signal peptide peptidase in propagation and pathogenesis of HCV.