HIF1α in aortic aneurysms and beyond.
HIF1α in aortic aneurysms and beyond.
复制标题
HIF1α 在主动脉瘤及其他疾病中的应用。
DOI：
10.1042/cs20160956
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Rizzo,Victor
中科院分区：
文献类型：
--
作者：
Hashimoto,Tomoki;Rizzo,Victor
腹主动脉瘤（AAA）是一种永久性的血管壁扩张，在65岁及以上的人群中发病率很高。动脉瘤容易发生剥离和破裂，死亡率超过85%。目前，手术修复是治疗这种疾病的唯一选择。需要在这些事件发生之前进行干预，这引发了一系列基础研究，以了解控制AAA形成、进展和破裂的细胞和分子机制。在本研究中，髓系细胞在AAA发展中的作用已得到证实。更具体地说，转录因子，缺氧诱导因子-1α (HIF1α)被证明是调节细胞外基质修饰酶及其内源性抑制剂表达的必要成分。这一新发现可能会导致治疗靶点，以禁止血管壁的降解和削弱，并希望限制AAA的形成和/或生长。
Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option to treat this disease. The need to intervene prior to these events has set off a flurry of basic studies in an effort to understand the cellular and molecular mechanisms that govern AAA formation, progression and rupture. In the present study, the role of myeloid cells in contributing to AAA development has been confirmed. More specifically, the transcription factor, hypoxia-inducible factor-1α (HIF1α), was demonstrated to be a necessary component for regulating the expression of extracellular matrix modifying enzymes and their endogenous inhibitors in these cells. This new discovery may lead to therapeutic targets to prohibit the degradation and weakening of the vessel wall with the hope of limiting AAA formation and/or growth.