Rate and pattern of epithelial cell proliferation in ulcerative colitis.
Rate and pattern of epithelial cell proliferation in ulcerative colitis.
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DOI：
10.1136/gut.22.8.648
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发表时间：
1981-08
期刊：
影响因子：
24.5
通讯作者：
E. P. Serafini;A. Kirk;T. J. Chambers
中科院分区：
文献类型：
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作者：
E. P. Serafini;A. Kirk;T. J. Chambers
我们研究了正常人和溃疡性结肠炎患者直肠粘膜上皮细胞增殖的模式，通过体外培养粘膜与氚化胸苷和放射自显影处理。我们发现，溃疡性结肠炎缓解期患者表现出与再生和“癌前”粘膜相似的增殖模式。病史短的患者与病史长的患者一样可能表现出这种模式，这表明异常模式并不意味着即将发生恶变。我们还发现，缓解期溃疡性结肠炎患者的粘膜显示出合成DNA的细胞比例增加，这一比例惊人地接近活动期的比例;这表明缓解期的异常模式是再生粘膜的模式。我们认为，不仅在临床活动性疾病期间，而且在整个缓解期，粘膜更新率都很高，这导致了癌发生率的增加和扁平粘膜癌的发展。
We investigated the pattern of proliferation of epithelial cells in rectal mucosa taken from normal individuals and patients with ulcerative colitis by incubating mucosa with tritiated thymidine in vitro and processing for autoradiography. We found that patients with ulcerative colitis in remission showed a proliferative pattern similar to that seen in both regenerating and "precancerous' mucosa. Patients with a short history were as likely to show this pattern as those with a long history, and this shows that the abnormal pattern does not signify impending malignant change. We also found that mucosa from patients with ulcerative colitis in remission showed an increased proportion of cells synthesising DNA, a proportion surprisingly close to that seen in an active phase; this suggests that the abnormal pattern seen in remission is the pattern of a regenerating mucosa. We feel that this high rate of mucosal turnover, sustained not just during clinically active disease but throughout remission, leads to the increased incidence of carcinoma and to the development of carcinoma in flat mucosa.