Role of autophagy in cancer
Role of autophagy in cancer
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DOI：
10.1038/nrc2254
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发表时间：
2007-12-01
影响因子：
78.5
通讯作者：
White, Eileen
中科院分区：
文献类型：
--
作者：
Mathew, Robin;Karantza-Wadsworth, Vassiliki;White, Eileen
自噬是一种细胞降解途径，用于清除受损或多余的蛋白质和细胞器。在代谢应激期间，这些细胞内成分的回收也是维持稳态和生存能力的替代能源。在凋亡缺陷的肿瘤细胞中，自噬允许长时间的存活率。自相矛盾的是，自噬缺陷与肿瘤发生增加有关，但尚未确定其背后的机制。最近的证据表明，自噬提供了一种保护功能来限制肿瘤坏死和炎症，并响应代谢胁迫而减轻肿瘤细胞中的基因组损伤。
Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative energy source during periods of metabolic stress to maintain homeostasis and viability. In tumour cells with defects in apoptosis, autophagy allows prolonged survival. Paradoxically, autophagy defects are associated with increased tumorigenesis, but the mechanism behind this has not been determined. Recent evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress.