Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium Wilfordii Hook F
Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium Wilfordii Hook F
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DOI：
10.3109/10428190109064582
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发表时间：
2001-07-01
影响因子：
2.6
通讯作者：
Chen, BJ
中科院分区：
文献类型：
--
作者：
Chen, BJ
雷公藤内酯醇是从中药雷公藤中分离得到的一种二萜类三环氧化物。TWHF在中国传统医学中已经使用了两千多年。然而，直到研究者观察了雷公藤多甙治疗麻风病和类风湿关节炎的有效性后，其潜在价值才被西方医学所认识。雷公藤内酯醇已被确定为负责TWHF的免疫抑制和抗炎作用的主要成分。雷公藤内酯醇抑制Ca 2+依赖性和Ca 2+非依赖性途径，并通过在不同于环孢菌素A靶点的位点抑制白细胞介素-2转录来影响T细胞活化。雷公藤内酯醇还对多种促炎细胞因子和介质以及内皮细胞粘附分子的表达具有抑制作用。雷公藤内酯醇对多种自身免疫性疾病有治疗作用，对同种异体移植排斥反应和移植物抗宿主病有预防作用，并具有抗肿瘤和抗雄性不育作用。然而，雷公藤内酯醇的毒性可能与肾脏、心脏、造血和生殖系统有关。现有资料表明，雷公藤内酯醇是一种很有前途的免疫抑制和抗炎剂，在自身免疫性疾病和移植方面值得进一步研究。
Triptolide is a diterpenoid triepoxide purified from a Chines herb Tripterygium Wilfordii Hook F (TWHF). TWHF has been used in traditional Chinese medicine for more than two thousand years. However, its potential value was recognized by the western medicine only after investigators observed the effectiveness of TWHF in the treatment of leprosy and rheumatoid arthritis. Triptolide has been identified as the major component responsible for the immuno suppressive and anti-inflammatory effects of TWHF. Triptolide inhibits both Ca2+-dependent and Ca2+-independent pathways and affects T cell activation through inhibition of interleukin-2 transcription at a site different from the target of cyclosporin A. Triptolide also has inhibitory effects on a variety of proinflammatory cytokines and mediators and on the expression of adhesion molecules by endothelial cells. Triptolide is effective for the treatment of a variety of autoimmune diseases and in prevention of allograft rejection and graft-versus-host disease in both animals and humans, Moreover, triptolide posseses antitumor and male anti-fertility effect. However, the toxicities of triptolide may be associated with renal, cardiac, hematopoietic and reproductive systems. Currently available data suggest that triptolide is a promising immuno suppressive and anti-inflammatory agent and should be explored further in autoimmune, diseases and transplantation.