Aberrant Igh locus rearrangements in A-MuLV pre B lines of scid mice: evidence for deregulated D-J recombination.
Aberrant Igh locus rearrangements in A-MuLV pre B lines of scid mice: evidence for deregulated D-J recombination.
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scid 小鼠 A-MuLV pre B 系中异常的 Igh 基因座重排：D-J 重组失调的证据。
DOI：
10.1007/978-3-642-50059-6_30
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发表时间：
1988
影响因子：
--
通讯作者：
Marcu,KB
中科院分区：
文献类型：
--
作者：
Kim,MG;Schuler,W;Bosma,MJ;Marcu,KB
Severe combined immune deficiency (scid) in mice is a recessive mutation (Bosma et al., 1983) . Mice with this defect contain myeloid cells but no functional B and T cells indicating that their early lymphoid differentiation is defective. A-MuLV transformed, bone marrow derived pre B cells and spontaneous thymic lymphomas fromscidanimals displayed abnormal immunoglobulin and T cell receptor gene rearrangements with deletions around the J regions which may be a consequence of faulty D-J joining (Schuler et at., 1986) . We have analysed the rearrangedIghloci in nine A-MuLV transformedscidpre B lines in some detail by Southern blotting and have determined the nucleotide sequences in the vicinity of two such aberrant Igh recombinations. We find that Igh locus deletions inscidpre B cells can involve up to all the DHsegments but do not extend to the VHgene families. DHand JHcoding sequences are both deleted at the site of recombination: Normal heptamer-nonamer recombination signal sequences separated by proper spacer lengths are not present but “heptamer like” sequences are found 5’ of the recombination sites. These findings lend support to the idea that a deregulated, error prone D-J recombination contributes to thesciddefect early in B and T cell development.
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