Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
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DOI：
10.1016/j.jalz.2014.05.1758
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发表时间：
2015-06-01
影响因子：
14
通讯作者：
Ikram, M. Arfan
中科院分区：
文献类型：
--
作者：
Bos, Daniel;Vernooij, Meike W.;Ikram, M. Arfan
背景：关于不同血管床动脉粥样硬化在认知障碍和痴呆病因学中的作用的纵向数据很少且不一致。方法：2003-2006年间，2364名非痴呆患者接受了冠状动脉、主动脉弓、颅外和颅内颈动脉的计算机断层扫描，以量化动脉粥样硬化钙化。随访参与者的痴呆发生率（n = 90），直至2012年4月。在基线和随访时，参与者也接受了认知测试。结果：除冠状动脉外，所有血管中较大的钙化体积与痴呆的高风险相关。在校正相关混杂因素后，颅外颈动脉钙化仍然与痴呆的高风险显著相关[钙化体积每标准差增加的风险比：1.37(1.05,1.79)]。仅对阿尔茨海默病或对中风进行审查的其他分析也显示出类似的结果。较大的钙化体积也与认知能力下降有关。结论：动脉粥样硬化，特别是颅外颈动脉粥样硬化，与痴呆和认知能力下降的高风险有关。(C) 2015年阿尔茨海默病协会。Elsevier Inc.出版。版权所有。
Background: Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairment and dementia are scarce and inconsistent.Methods: Between 2003-2006, 2364 nondemented persons underwent computed tomography of the coronaries, aortic arch, extracranial, and intracranial carotid arteries to quantify atherosclerotic calcification. Participants were followed for incident dementia (n = 90) until April 2012. At baseline and follow-up participants also underwent a cognitive test battery.Results: Larger calcification volume in all vessels, except in the coronaries, was associated with a higher risk of dementia. After adjustment for relevant confounders, extracranial carotid artery calcification remained significantly associated with a higher risk of dementia [hazard ratio per standard deviation increase in calcification volume: 1.37 (1.05, 1.79)]. Additional analyses for Alzheimer's disease only or censoring for stroke showed similar results. Larger calcification volumes were also associated with cognitive decline.Conclusions: Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.