An investigation into the distribution of different collagen types within adult and juvenile porcine pancreata
An investigation into the distribution of different collagen types within adult and juvenile porcine pancreata
复制标题
成年猪和幼年猪胰腺内不同胶原类型分布的研究
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
N. London
中科院分区：
文献类型：
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作者：
S. White;D. P. Hughes;H. Contractor;N. London
One of the difficulties of porcine islet isolation is their fragility during collagenase digestion. The object of this study was to determine the distribution of 4 different collagen types within adult and juvenile porcine pancreata. Five different areas from each pancreas were analysed by light microscopy. The distribution of collagen types I, IV, V and VI were measured within the interlobar, intralobular (acinar), peri-insular and intra-islet regions. Their was an abundance of collagen type VI compared to I, IV and V in both the interlobar and intralobular septa in both juveniles (P<0.001) and adults (P<0.001). The peri-insular collagen content also showed diversity. This was mainly attributable to the distribution of collagen type I (weak) and type VI (intense) in both adults and juveniles. In general, the peri-insular capsule was fragmentary and contained less than 50% of the total islet circumference. The latter finding taken together with the distributions of different collagen types can partly explain some of the variability of porcine islet isolation.
