Tandem duplication of the proviral DNA in an avian sarcoma virus-transformed quail clone.
Tandem duplication of the proviral DNA in an avian sarcoma virus-transformed quail clone.
复制标题
禽肉瘤病毒转化的鹌鹑克隆中原病毒 DNA 的串联复制。
DOI：
10.1128/jvi.38.1.219-223.1981
复制
发表时间：
1981
影响因子：
5.4
通讯作者：
Mason,WS
中科院分区：
文献类型：
--
作者：
Hsu,TW;Taylor,JM;Aldrich,C;Townsend,JB;Seal,G;Mason,WS
Previous study has shown that an avian sarcoma virus-transformed quail clone, Q-B77-11, apparently contains full-size proviral DNA and releases virus particles which contain polymerase activity, but are unable to form foci. Recently, we have found that after extended tissue culture of Q-B77-11, the predominant cell type changed from one in which there was a single copy of the integrated viral DNA to one with two copies in tandem. There was approximately one copy of the large terminal redundancy between these two tandem proviruses. Polyadenylic acid-containing RNA species of twice the size of the viral genome were detected in these cells and are interpreted as transcripts of the tandem provirus.
