Further development of the ketoxime-based pyrrole synthesis
Further development of the ketoxime-based pyrrole synthesis
复制标题
酮肟基吡咯合成的进一步发展
DOI：
10.3987/rev-93-sr6
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发表时间：
1994
期刊：
影响因子：
0.6
通讯作者：
A. Mikhaleva
中科院分区：
文献类型：
--
作者：
B. Trofimov;A. Mikhaleva
本文综述了在强碱性KOH/DMSO催化消除对存在下，酮肟与乙炔及其合成等价物（卤代乙烯和二卤代烷）反应（Trofimov反应）合成吡咯和1-乙烯基吡咯的最新进展和改进。讨论了3 H-吡咯和其它可分离的中间体（O-乙烯基酮肟和羟基吡咯啉）以及副产物的形成
Recent development and modification of the general synthesis of pyrroles and 1-vinylpyrroles by the reaction of ketoximes with acetylenes and their synthetic equivalents (vinyl halides and dihaloalkanes) in the presence of the strongly basic KOH/DMSO catalytic and eliminating pair (the Trofimov reaction) are briefly reviewed. The formation of 3H-pyrroles and other isolable intermediates (O-vinyl ketoximes and hydroxypyrrolines) as well as side products are discussed