Fall-related risk factors and osteoporosis in women with rheumatoid arthritis
Fall-related risk factors and osteoporosis in women with rheumatoid arthritis
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DOI：
10.1093/rheumatology/keh304
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发表时间：
2004-10-01
期刊：
影响因子：
5.5
通讯作者：
Patel, S
中科院分区：
文献类型：
--
作者：
Kaz, HK;Johnson, D;Patel, S
背景风湿性关节炎（RA）与骨质疏松性骨折的风险增加有关。虽然许多研究已经证明RA的骨密度低，但很少有研究检查跌倒的风险，这是骨折（特别是髋部骨折）发病机制的另一个主要因素。本研究的目的是观察类风湿关节炎女性患者跌倒风险是否增加，确定高风险亚组，并确定由于骨质疏松和跌倒风险增加而导致髋部骨折风险增加的女性比例。我们进行了一项病例对照研究，老年女性类风湿关节炎（n = 103）相比，妇女没有类风湿关节炎开放访问骨密度测定（n = 203）。我们使用双能X线吸收法和跌倒危险因素（视力、站立能力和脚跟-脚趾行走）测量骨密度。与对照组相比，更多的RA女性有既往跌倒史（54 vs 44%），尽管这只是统计学显著性差异（差异10%，95%CI-2至22）。与对照组相比，RA女性患者更容易出现脚跟-脚趾行走异常和站立不稳（P
Background. Rheumatoid arthritis (RA) is associated with an increased risk of osteoporotic fractures. Whilst numerous studies have demonstrated low bone density in RA, few studies have examined the risk of falling, which is another major contributor to the pathogenesis of fractures (particularly hip fractures).Objectives. The aim of this study was to see if fall risk is increased in women with RA, define high-risk subgroups, and determine what proportion of women have increased risk of hip fracture due to osteoporosis and due to increased fall risk.Methods. We performed a case-control study of older women with RA (n = 103) compared with women without RA referred for open access bone densitometry (n = 203). We measured bone density using dual-energy X-ray absorptiometry and fall risk factors (visual acuity, ability to perform standups, and heel-toe walking).Results. More women with RA gave a history of a previous fall compared with controls (54 vs 44%), although this was just short of being statistically significant (difference 10%, 95% CI -2 to 22). Women with RA were more likely to have abnormal heel-toe walking and inability to perform standups compared with controls (P