The distribution of laminin in human brain tumors: An immunohistochemical study
The distribution of laminin in human brain tumors: An immunohistochemical study
复制标题
层粘连蛋白在人脑肿瘤中的分布：免疫组织化学研究
DOI：
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发表时间：
2004
影响因子：
12.7
通讯作者：
Davide Schiffer
中科院分区：
文献类型：
--
作者：
M. Giordana;I. Germano;Giorgio Giaccone;A. Mauro;A. Migheli;Davide Schiffer
SummaryThe immunohistochemical distribution of laminin in 70 cases of primary and secondary brain tumors has been studied. The sections were fixed in Carnoy, embedded in paraffin, and treated with collagenase before applying the specific immune serum. In normal neural tissue and in gliomas, the distribution of laminin overlaps with that of basement membrane, as is known from observations on ultrastructure in the literature. The overlapping was observed also in neurinomas, papillomas of the choroid plexus, ependymomas, and meningiomas. Problems arise in the interpretation of the results in the other oncotypes. In hemangiopericytomas and hemangioblastomas, laminin demonstrates a basement membrane around the vessels only; it is absent around stromal cells. In desmoplastic medulloblastomas, laminin forms a network among the tumor celis. In primary lymphomas, concentric rings of laminin are evidenced around some vessels. In discussing the results, the ultrastructural distribution of basement membranes is taken into account.
