PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction
PlGF and sFlt-1 levels in patients with non-transfusion-dependent thalassemia: Correlations with markers of iron burden and endothelial dysfunction
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DOI：
10.1111/ejh.13061
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发表时间：
2018-06-01
影响因子：
3.1
通讯作者：
Papassotiriou, Ioannis
中科院分区：
文献类型：
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作者：
Kelaidi, Charikleia;Kattamis, Antonis;Papassotiriou, Ioannis
背景血管生成细胞因子胎盘生长因子（PlGF）和可溶性Fms样酪氨酸激酶-1（sFlt-1）的水平以及由sFlt-1/PlGF比率表示的血管生成平衡在镰状细胞病和铁过载中受到干扰，但它们在非输血依赖性地中海贫血（NTDT）中尚未被评估。β-地中海贫血基因型NTDT患者的抗原，并将其与红细胞指数和铁过载，炎症和组织缺氧标志物相关。34例NTDT患者的平均血红蛋白水平为8.4 g/dL被列入研究沿着与20名明显健康的人谁作为controls.ResultsFerritin，LDH，和hs-CRP的患者相比，对照组。我们发现患者与对照组之间PlGF水平存在显著差异（52.2 vs 17.2pg/mL，P
BackgroundLevels of the angiogenic cytokines placental growth factor (PlGF) and soluble Fms-like tyrosine kinase-1 (sFlt-1) and the angiogenic balance, expressed by sFlt-1/PlGF ratio, are perturbed in sickle-cell disease and iron overload, but they have not been evaluated in non-transfusion-dependent thalassemia (NTDT).Patients and MethodsWe measured levels of PlGF, sFlt-1 and vWF:antigen in patients with NTDT of beta-thalassemia genotype, and correlated them with erythrocytic indices and markers of iron overload, inflammation, and tissue hypoxia. Thirty-four NTDT patients with mean hemoglobin level of 8.4g/dL were included in the study along with 20 apparently healthy individuals who served as controls.ResultsFerritin, LDH, and hs-CRP were higher in patients as compared to controls. We found significant differences between patients and controls in regard to levels of PlGF (52.2 vs 17.2pg/mL, P