Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors
Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors
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DOI：
10.3998/ark.5550190.0003.711
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发表时间：
2002-01-01
期刊：
影响因子：
0.9
通讯作者：
Tilekar, JN
中科院分区：
文献类型：
--
作者：
Dhavale, DD;Desai, VN;Tilekar, JN
New chiron approaches towards the syntheses of polyhydroxylated piperidine analogues are described. The methodologies involve 1,3-addition of methyl magnesium bromide and silyl ketene acetal to D-glucose derived nitrone, intramolecular Michael addition to D- glucose derived alpha, beta-unsaturated ester and double reductive amination of 5-keto aldose as key steps.
