The first synthesis of peptide thioester carrying N-linked core pentasaccharide through modified Fmoc thioester preparation:: synthesis of an N-glycosylated Ig domain of emmprin
The first synthesis of peptide thioester carrying N-linked core pentasaccharide through modified Fmoc thioester preparation:: synthesis of an N-glycosylated Ig domain of emmprin
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DOI：
10.1016/s0040-4039(03)00394-0
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发表时间：
2003-03-31
影响因子：
1.8
通讯作者：
Watanabe, Y
中科院分区：
文献类型：
--
作者：
Hojo, H;Haginoya, E;Watanabe, Y
采用Fmoc固相法，结合碳水化合物部分的苯保护策略，制备了携带n链核心五糖的肽硫酯。获得的肽硫酯成功地用于合成由61个氨基酸残基组成的emmprin的第一个Ig结构域。2003爱思唯尔科学有限公司版权所有。
Peptide thioester carrying N-linked core pentasaccharide was prepared by the Fmoc solid-phase method with a combination of the benzyl-protection strategy at the carbohydrate portion. The obtained peptide thioester was successfully used for the synthesis of the first Ig domain of emmprin composed of 61 amino acid residues. (C) 2003 Elsevier Science Ltd. All rights reserved.