CONTROLLED TRIAL OF HIGH SPERMATIC VEIN LIGATION FOR VARICOCELE IN INFERTILE MEN
CONTROLLED TRIAL OF HIGH SPERMATIC VEIN LIGATION FOR VARICOCELE IN INFERTILE MEN
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DOI：
10.1016/s0015-0282(16)57306-3
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发表时间：
1995-01-01
影响因子：
6.7
通讯作者：
GOLDWASSER, B
中科院分区：
文献类型：
--
作者：
MADGAR, I;WEISSENBERG, R;GOLDWASSER, B
目的：为了确定高位结扎术是否是一种有效的治疗方法，设计：进行了一项精索静脉高位结扎术的随机对照试验。研究对象为男性不育症治疗门诊和男科实验室，研究对象为单纯精索静脉曲张精液分析异常的男性不育症患者，干预措施为招募后1年（A组）和研究开始时（B组）行高位结扎术。在A组的20对夫妇中，2对（10%）在观察期的第一年内妊娠。术后1年内妊娠8例（44.4%），术后2年内妊娠4例（22.2%）。B组术后1年内妊娠15例（60%）。3例妊娠（12%）和1例妊娠（4%）分别发生在第2年和第3年。两组患者术后精液参数均有明显改善，无论是否妊娠。手术组B和非手术组A之间的怀孕率（PR）的差异在第一年的study.Conclusions被发现是非常显着的：它的结论是，在人口的不育男性提出精索静脉曲张不育症的唯一可证明的因素，精索静脉曲张是明确与不育症和睾丸功能降低，其纠正结扎提高精子参数和生育率。此外，两组的最高PR发生在术后第1年。
Objective: To determine whether high ligation is an effective treatment for inDesign: A randomized, controlled trial of high spermatic vein ligation was carried out. The patients were treated and observed for 3 years.Setting: Infertility treatment clinic and andrology laboratory in a hospital.Patients: Infertile men with abnormal semen analysis because of varicocele only.Intervention: High ligation I year postrecruitment (group A) and at the beginning of the study (group B).Results: Among the 20 couples in group A, 2 pregnancies (10%) were achieved within the Ist year of observation period. During the year after high ligation, there were 8 pregnancies (44.4%), and during the 2nd year after high ligation, there were 4 more pregnancies (22.2%). In group B, 15 pregnancies (60%) occurred within the Ist year after operation. Three pregnancies (12%) and 1 pregnancy (4%) occurred during the 2nd and 3rd year, respectively. After operation in all patients of both groups, there was significant improvement in semen parameters, regardless of pregnancy occurrence. The difference in pregnancy rate (PR) between the operated group B and nonoperated group A during the Ist year of study was found to be highly significant.Conclusions: It is concluded that in a population of infertile men presenting varicocele as the only demonstrable factor of infertility, the varicocele is clearly associated with infertility and reduced testicular function, and its correction by ligation improves sperm parameters and fertility rate. Furthermore, the highest PR in both groups occurred during the Ist year postoperation.