Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence
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DOI：
10.1523/jneurosci.21-23-09414.2001
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发表时间：
2001-12-01
影响因子：
5.3
通讯作者：
Logan, J
中科院分区：
文献类型：
--
作者：
Volkow, ND;Chang, L;Logan, J
甲基苯丙胺是一种常见的滥用药物，当给实验动物服用时，它会对多巴胺 (DA) 末端产生神经毒性。对甲基苯丙胺滥用者的研究还记录了 DA 转运蛋白（用作 DA 末端标记）的显着损失，这与运动功能减慢和记忆力下降有关。 DA转运蛋白的缺失在多大程度上使甲基苯丙胺滥用者容易患上帕金森病等神经退行性疾病，目前尚不清楚，可能部分取决于恢复程度。在这里，我们使用正电子发射断层扫描和[C-11]d-苏型哌甲酯（DA 转运蛋白放射性配体）评估了长期戒酒对甲基苯丙胺滥用者纹状体中 DA 转运蛋白损失的影响。对 5 名甲基苯丙胺滥用者在短期戒断期间的脑 DA 转运蛋白进行了评估（
Methamphetamine is a popular drug of abuse that is neurotoxic to dopamine (DA) terminals when administered to laboratory animals. Studies in methamphetamine abusers have also documented significant loss of DA transporters (used as markers of the DA terminal) that are associated with slower motor function and decreased memory. The extent to which the loss of DA transporters predisposes methamphetamine abusers to neurodegenerative disorders such as Parkinsonism is unclear and may depend in part on the degree of recovery. Here we assessed the effects of protracted abstinence on the loss of DA transporters in striatum, in methamphetamine abusers using positron emission tomography and [C-11]d-threo-methylphenidate (DA transporter radioligand). Brain DA transporters in five methamphetamine abusers evaluated during short abstinence (