Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex.
Experience-dependent plasticity of dendritic spines of layer 2/3 pyramidal neurons in the mouse cortex.
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DOI：
10.1002/dneu.22313
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发表时间：
2016-03
影响因子：
3
通讯作者：
Gan WB
中科院分区：
文献类型：
--
作者：
Ma L;Qiao Q;Tsai JW;Yang G;Li W;Gan WB
以往的研究表明，感觉和运动经验在皮层第5层锥体神经元树突棘的重塑中起着重要作用。在这项研究中，我们研究了感觉剥夺和运动学习对桶和运动皮层2/3层锥体神经元树突棘重塑的影响。与第5层锥体神经元类似，第2/3层锥体神经元的顶树突上的棘在发育期间是可塑的，并且在成年期基本上是稳定的。通过胡须修剪的感觉剥夺降低了现有棘的消除率，但对发育中的桶皮质中棘的形成率没有显著影响。此外，我们表明，运动训练增加了初级运动皮层树突棘的形成和消除。然而，与第5层锥体神经元不同，第2/3层锥体神经元的兄弟树突分支之间的棘形成率没有显著差异。我们的研究表明，感觉和运动学习经历对2/3层锥体神经元树突棘重塑有重要影响。他们还表明，在第2/3层和第5层锥体神经元之间，经验依赖性脊柱重塑的规则在很大程度上是相似的，但不完全相同。
Previous studies have shown that sensory and motor experiences play an important role in the remodeling of dendritic spines of layer 5 pyramidal neurons in the cortex. In this study, we examined the effects of sensory deprivation and motor learning on dendritic spine remodeling of layer 2/3 pyramidal neurons in the barrel and motor cortices. Similar to layer 5 pyramidal neurons, spines on apical dendrites of layer 2/3 pyramidal neurons are plastic during development and largely stable in adulthood. Sensory deprivation via whisker trimming reduces the elimination rate of existing spines without significant effect on the rate of spine formation in the developing barrel cortex. Furthermore, we show that motor training increases the formation and elimination of dendritic spines in the primary motor cortex. Unlike layer 5 pyramidal neurons, however, there is no significant difference in the rate of spine formation between sibling dendritic branches of layer 2/3 pyramidal neurons. Our studies indicate that sensory and motor learning experiences have important impact on dendritic spine remodeling in layer 2/3 pyramidal neurons. They also suggest that the rules governing experience-dependent spine remodeling are largely similar, but not identical, between layer 2/3 and layer 5 pyramidal neurons.