Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.
Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease.
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DOI：
10.1016/j.jneuroim.2018.03.003
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发表时间：
2018-06-15
影响因子：
3.3
通讯作者：
Leverenz JB
中科院分区：
文献类型：
--
作者：
Bekris LM;Khrestian M;Dyne E;Shao Y;Pillai JA;Rao SM;Bemiller SM;Lamb B;Fernandez HH;Leverenz JB
阿尔茨海默病（AD）在遗传和病理上与神经炎症相关。髓样细胞上表达的触发受体2（TREM2）是参与先天免疫的小胶质细胞受体。TREM2罕见蛋白编码遗传变异与AD有关。可溶性TREM2（sTREM2）裂解产物在AD中升高。目前尚不清楚sTREM2升高与炎症标志物之间是否存在关系。这项研究的假设是，中枢和外周炎症在AD中的sTREM2水平中起作用。未发现外周或中枢炎症标志物与CSF sTREM2水平的一致关联，表明全身炎症对sTREM2水平的影响有限。在AD中观察到外周sTREM2水平与CSF sTREM2之间的关联，以及CSF sTREM2与血脑屏障完整性标志物之间的关联，表明外周TREM2在中枢TREM2生物学中的潜在作用。观察到CSF sTREM2与血脑屏障完整性之间的相关性。此外，在AD中，CSF sTREM2与血浆sTREM2相关。总之，这些结果暗示了外周TREM2在AD中的中枢TREM2生物学中的潜在作用。
Alzheimer’s disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology. A correlation between CSF sTREM2 and blood brain barrier integrity was observed. Furthermore, CSF sTREM2 correlated with plasma sTREM2 in AD. Taken together, these results implicate a potential role of peripheral TREM2 in central TREM2 biology in AD.
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DOI：
10.1056/nejmoa1211851
发表时间：
2013-01-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Guerreiro R;Wojtas A;Bras J;Carrasquillo M;Rogaeva E;Majounie E;Cruchaga C;Sassi C;Kauwe JS;Younkin S;Hazrati L;Collinge J;Pocock J;Lashley T;Williams J;Lambert JC;Amouyel P;Goate A;Rademakers R;Morgan K;Powell J;St George-Hyslop P;Singleton A;Hardy J;Alzheimer Genetic Analysis Group
通讯作者：
Alzheimer Genetic Analysis Group
DOI：
10.1084/jem.20142322
发表时间：
2015-03-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jay TR;Miller CM;Cheng PJ;Graham LC;Bemiller S;Broihier ML;Xu G;Margevicius D;Karlo JC;Sousa GL;Cotleur AC;Butovsky O;Bekris L;Staugaitis SM;Leverenz JB;Pimplikar SW;Landreth GE;Howell GR;Ransohoff RM;Lamb BT
通讯作者：
Lamb BT
DOI：
10.1046/j.1365-2362.2002.00994.x
发表时间：
2002-05-01
影响因子：
5.5
作者：
Fiala, M;Liu, QN;Vinters, HV
通讯作者：
Vinters, HV
TREM2上调与阿尔茨海默氏病海马的5-羟基环胞嘧啶富集相关。
影响因子：
5.7
作者：
Celarain N;Sánchez-Ruiz de Gordoa J;Zelaya MV;Roldán M;Larumbe R;Pulido L;Echavarri C;Mendioroz M
通讯作者：
Mendioroz M
影响因子：
3.5
作者：
Jin, Sheng Chih;Benitez, Bruno A.;Cruchaga, Carlos
通讯作者：
Cruchaga, Carlos