NAD+/sirtuin metabolism is enhanced in response to cold-induced changes in lipid metabolism in mouse liver.
NAD+/sirtuin metabolism is enhanced in response to cold-induced changes in lipid metabolism in mouse liver.
复制标题
NAD/sirtuin 代谢因寒冷引起的小鼠肝脏脂质代谢变化而增强。
DOI：
10.1002/1873-3468.13779
复制
发表时间：
2020
期刊：
影响因子：
3.5
通讯作者：
Xiao Luo
中科院分区：
文献类型：
--
作者：
Xiaojing Wei;Ru Jia;Zhao Yang;Jianan Jiang;Jiaqi Huang;Jianqun Yan;Xiao Luo
烟酰胺腺嘌呤二核苷酸（NAD+）/Sirtuin（SIRT）系统与代谢适应有关。本研究旨在确定肝脏对冷暴露的代谢反应的时间曲线和肝脏NAD+/SIRT系统的变化。将8周龄雄性C57 BL/6小鼠单独圈养在常规笼中，在冷暴露（4 °C）下长达5天。冷暴露使小鼠的肝脏甘油三酯水平和胆固醇水平分别降低了1.7倍和1.6倍。脂肪生成基因表达持续减少，而脂肪生成基因表达短暂增加。肝脏NAD+/SIRT代谢在“冷重塑”阶段（第1-3天）被诱导，并与脂肪生成基因表达降低和脂肪生成基因表达增加相关，有助于维持全身脂质和葡萄糖稳态。
The nicotinamide adenine dinucleotide (NAD+)/Sirtuin (SIRT) system is linked to metabolic adaptation. This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes in the hepatic NAD+/SIRT system. Eight‐week‐old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4 °C) for up to 5 days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7‐ and 1.6‐fold, respectively. Lipogenic gene expression was persistently reduced, while gluconeogenic gene expression was transiently increased. Hepatic NAD+/SIRT metabolism was induced during the ‘cold remodeling’ phase (days 1–3) and correlated with decreasing lipogenic and increasing gluconeogenic gene expression, contributing to the maintenance of whole‐body lipid and glucose homeostasis.