Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort - The Suita Study
Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort - The Suita Study
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DOI：
10.1161/hypertensionaha.108.118273
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发表时间：
2008-10-01
期刊：
影响因子：
8.3
通讯作者：
Kawano, Yuhei
中科院分区：
文献类型：
--
作者：
Kokubo, Yoshihiro;Kamide, Kei;Kawano, Yuhei
在亚洲，很少有前瞻性研究调查了高正常血压与心血管疾病（CVD）之间的关系。我们研究了高正常血压对日本普通城市人群心血管疾病发病率的影响。我们研究了5494名日本人（年龄30 - 79岁，无心血管疾病），完成了基线调查，随访至2005年12月。根据ESH-ESC 2007标准定义血压类别。在64391人年的随访中，我们记录了346例CVD事件的发生率。高正常血压和高血压1期和>= 2期的频率男性分别为18.0%、20.1%和10.1%，女性分别为15.9%、15.6%和8.8%。降压药使用者也被分为基线血压类别。与最佳血压组相比，男性正常、高正常血压和高血压1期和>= 2期的多变量风险比（95%可信区间）分别为2.04（1.19 ~ 3.48）、2.46（1.46 ~ 4.14）、2.62（1.59 ~ 4.32）和3.95(2.37 ~ 6.58)，女性分别为1.12（0.59 ~ 2.13）、1.54（0.85 ~ 2.78）、1.35（0.75 ~ 2.43）和2.86（1.60 ~ 5.12）。每个血压类别的心肌梗死和中风的风险与心血管疾病相似。心血管疾病导致的高正常血压和高血压的人群归因比例在男性中分别为12.2%和35.3%，在女性中分别为7.1%和23.4%。综上所述，在日本城市男性中，高血压是中风和心肌梗死发生的一个危险因素。
Few prospective studies have examined the association between high-normal blood pressure and cardiovascular disease (CVD) in Asia. We examined the impact of high-normal blood pressure on the incidence of CVD in a general urban population cohort in Japan. We studied 5494 Japanese individuals (ages 30 to 79 years without CVD at baseline) after completing a baseline survey who received follow-up through December 2005. Blood pressure categories were defined on the basis of the ESH-ESC 2007 criteria. In 64 391 person-years of follow-up, we documented the incidence of 346 CVD events. The frequencies of high-normal blood pressure and hypertension Stage 1 and Stage >= 2 were 18.0%, 20.1%, and 10.1% for men and 15.9%, 15.6%, and 8.8% for women, respectively. Antihypertensive drug users were also classified into the baseline blood pressure categories. Compared with the optimal blood pressure group, the multivariable hazard ratios (95% confidence intervals) of CVD for normal and high-normal blood pressure and hypertension Stage 1 and Stage >= 2 were 2.04 (1.19 to 3.48), 2.46 (1.46 to 4.14), 2.62 (1.59 to 4.32), and 3.95 (2.37 to 6.58) in men and 1.12 (0.59 to 2.13), 1.54 (0.85 to 2.78), 1.35 (0.75 to 2.43), and 2.86 (1.60 to 5.12) in women, respectively. The risks of myocardial infarction and stroke for each blood pressure category were similar to those of CVD. Population-attributable fractions of high-normal blood pressure and hypertension for CVD were 12.2% and 35.3% in men and 7.1% and 23.4% in women, respectively. In conclusion, high-normal blood pressure is a risk factor for the incidence of stroke and myocardial infarction in a general urban population of Japanese men.