Phenotypic screens as a renewed approach for drug discovery.
Phenotypic screens as a renewed approach for drug discovery.
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DOI：
10.1016/j.drudis.2013.07.001
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发表时间：
2013-11
影响因子：
7.4
通讯作者：
McKew JC
中科院分区：
文献类型：
--
作者：
Zheng W;Thorne N;McKew JC
过去十年新批准药物数量的大幅减少部分归因于新靶点发现和验证的失败。对最近批准的新药的评估表明，通过表型筛选（一种原始药物筛选范式）发现的批准药物数量已经超过了通过基于分子靶点的方法发现的数量。因此，表型筛选在药物发现中获得了新的动力，希望这种方法可以通过发现可行的先导化合物和识别新的药物靶点来重振药物发现并提高药物批准的成功率。
The significant reduction in the number of newly approved drugs in past decade has been partially attributed to failures in discovery and validation of new targets. Evaluation of recently approved new drugs has revealed that the number of approved drugs discovered through phenotypic screens, an original drug screening paradigm, has exceeded those discovered through the molecular target-based approach. Phenotypic screening is thus gaining new momentum in drug discovery with the hope that this approach may revitalize drug discovery and improve the success rate of drug approval through the discovery of viable lead compounds and identification of novel drug targets.