Construction of allylic amino acid derivatives through a catalytic asymmetric allylic alkylation of azlactones with vinyl cyclopropanes
Construction of allylic amino acid derivatives through a catalytic asymmetric allylic alkylation of azlactones with vinyl cyclopropanes
复制标题
通过二氢唑酮与乙烯基环丙烷的催化不对称烯丙基烷基化构建烯丙基氨基酸衍生物
DOI：
10.1016/j.tetlet.2020.151694
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发表时间：
2020-03-26
影响因子：
1.8
通讯作者：
Cai, Xiaoqing
中科院分区：
文献类型：
--
作者：
Liu, Zhenquan;Feng, Xing;Cai, Xiaoqing
建立了一种简单、简明的氮内酯不对称烯丙基烷基化反应，用于直接合成四元氨基酸衍生物。亲电合成乙烯基丙烷在钯催化剂的存在下，在温和的条件下，以良好到极好的产率和较高的立体选择性得到了所需的季烯丙基氨基酸衍生物。(C)2020爱思唯尔有限公司。保留所有权利。
A simple and concise asymmetric allylic alkylation of azlactones was developed for direct construction of quaternary amino acid derivatives. Electrophilic synthons vinyl propanes were used in the presence of Pd catalyst under mild conditions, which afforded the desired quaternary allylic amino acid derivatives in good to excellent yields with a high level of stereoselectivity. (C) 2020 Elsevier Ltd. All rights reserved.