Changes in quality of life over 1 year in patients with head and neck cancer
Changes in quality of life over 1 year in patients with head and neck cancer
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DOI：
10.1001/archoto.2007.43
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发表时间：
2008-03-01
影响因子：
--
通讯作者：
Terrell, Jeffrey E.
中科院分区：
文献类型：
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作者：
Ronis, David L.;Duffy, Sonia A.;Terrell, Jeffrey E.
目的：描述和比较头颈部癌患者在初次治疗前不久和1年后的生活质量（QOL），并研究1年后QOL变化的预测因素。设计：前瞻性队列研究。设置：3个耳鼻喉科诊所。患者：316例新诊断为鳞状细胞头颈部癌的患者。主要结果测量：健康相关的生活质量进行了评估，使用36项简表健康调查和头颈部癌症的具体QOL scale.Results：超过一年，生活质量下降的身体功能的措施和饮食，但改善心理健康的生活质量。抑郁和吸烟是基线生活质量不佳的主要预测因素。QOL从基线到第1年变化的主要预测因素是治疗因素，尤其是饲管放置（9个量表）、化疗（3个量表）和放疗（Q量表）。基线吸烟和抑郁症状也仍然是显着的预测几个QOL量表在I year.Conclusions：健康相关的身体QOL倾向于下降超过I年和心理健康QOL改善。生活质量变化的主要预测因素是治疗因素、吸烟和抑郁症状。医生应提醒患者不同治疗对生活质量的相对影响。
Objectives: To characterize and compare quality of life (QOL) in patients with head and neck cancer shortly before initial treatment and I year later and to study the predictors of changes in QOL over 1 year.Design: Prospective cohort study.Setting: Three otolaryngology clinics.Patients: Three hundred sixteen patients having newly diagnosed squamous cell head and neck cancer.Main Outcome Measure: Health-related QOL was assessed using the 36-item Short-Form Health Survey and a head and neck cancer-specific QOL scale.Results: Over I year, QOL decreased for physical functioning measures and eating but improved for mental health QOL. Depression and smoking were major predictors of poor QOL at baseline. Major predictors of change in QOL from baseline to I year were treatment factors, especially feeding tube placement (9 scales), chemotherapy (3 scales), and radiation therapy Q scales). Baseline smoking and depressive symptoms also remained significant predictors of several QOL scales at I year.Conclusions: Health-related physical QOL tended to decline over I year and mental health QOL improved. The major predictors of change in QOL were treatment factors, smoking, and depressive symptoms. Physicians should alert patients to the relative effects on QOL one may experience with different treatments.