Vocal fold augmentation with injectable polycaprolactone microspheres/pluronic F127 hydrogel: long-term in vivo study for the treatment of glottal insufficiency.
Vocal fold augmentation with injectable polycaprolactone microspheres/pluronic F127 hydrogel: long-term in vivo study for the treatment of glottal insufficiency.
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DOI：
10.1371/journal.pone.0085512
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Kwon SK;Kim HB;Song JJ;Cho CG;Park SW;Choi JS;Ryu J;Oh SH;Lee JH
声门功能不全的重建需求日益增加。为此研究了几种注射材料，但它们都有局限性，如长期耐用性差，从注射部位迁移，炎症，肉芽肿形成，以及由于粘弹性不匹配而干扰声带振动。在这里，我们开发了一种新型注射材料，由具有比传统材料更好的粘弹性的聚己内酯（PCL）微球和Pluronic F127载流子组成，可以减少注射材料的迁移。将该材料注射到声门功能不全家兔体内，并与fda批准的注射材料羟基磷灰石钙（CaHA）进行比较。内镜和组织学检查显示PCL/Pluronic F127留在注射部位，无炎症反应或肉芽肿形成，而CaHA从注射部位渗出并迁移。因此，在本研究的12个月随访期间，声带增强几乎完全保留。此外，诱导发声和高速记录声带振动显示PCL/Pluronic F127组声带间隙面积减小。我们新开发的注射材料PCL/Pluronic F127，可以有效地增强瘫痪的声带，没有并发症，这一概念可以应用于临床，成功的长期随访证明了这一点。
There is increasing demand for reconstruction of glottal insufficiency. Several injection materials have been examined for this purpose, but all had limitations, such as poor long-term durability, migration from the injection site, inflammation, granuloma formation, and interference with vocal fold vibration due to viscoelastic mismatch. Here, we developed a novel injection material, consisting of polycaprolactone (PCL) microspheres, which exhibits better viscoelasticity than conventional materials, and Pluronic F127 carrier, which decreases the migration of the injection materials. The material was injected into rabbits with glottal insufficiency and compared with the FDA-approved injection material, calcium hydroxylapatite (CaHA). Endoscopic and histological examinations indicated that PCL/Pluronic F127 remained at the injection site with no inflammatory response or granuloma formation, whereas CaHA leaked out and migrated from the injection site. Therefore, vocal fold augmentation was almost completely retained during the 12-month follow-up period in this study. Moreover, induced phonation and high-speed recording of vocal fold vibration showed decreased vocal fold gap area in the PCL/Pluronic F127 group. Our newly developed injection material, PCL/Pluronic F127, permits efficient augmentation of paralyzed vocal fold without complications, a concept that can be applied clinically, as demonstrated by the successful long-term follow-up.
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影响因子：
1.7
作者：
Courey, MS
通讯作者：
Courey, MS
影响因子：
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作者：
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作者：
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Rosen, Clark A.
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Chheda, Neil N.;Rosen, Clark A.;Postma, Gregory N.
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作者：
HIRANO, M;MORI, K;FUJITA, M
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FUJITA, M