Clinical implications of cellular biologic advances in periodontal regeneration.
Clinical implications of cellular biologic advances in periodontal regeneration.
复制标题
牙周再生细胞生物学进展的临床意义。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
K. M. Chung
中科院分区：
文献类型：
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作者：
S. Amar;K. M. Chung
众所周知，牙周组织保留再生能力；然而，目前的疗法无法实现可预测且一致的再生。牙周再生中的细胞和分子生物学研究有望加深对这一复杂现象的理解，并引导我们走向未来临床应用的新可能性。本文回顾了牙周膜的细胞和细胞外基质，以及牙周再生中涉及的细胞与基质和细胞与细胞的相互作用。最近的研究结果表明，牙周再生概括了形态发生、组织发生和细胞分化的过程，以及牙周膜发育过程中发生的细胞场迁移。据信一小群所谓的牙周干细胞负责维持牙周膜的稳态。这种细胞可能起源于牙乳头的晚期牙周间充质，被认为是能够分化为成牙骨质细胞、成骨细胞和牙周成纤维细胞的三能细胞。牙周再生细胞和分子生物学研究进展的临床意义可能包括未来在牙周再生中使用生物分子，包括未来使用生物分子改善再生愈合过程，使用生物活性可降解膜屏障引导组织再生以及将牙周干细胞接种到牙周缺损中。如果目前的趋势持续下去，临床医生可以期待看到牙周伤口愈合显着增强，以实现可预测的牙周再生。
It is known that periodontal tissues retain the ability to regenerate; however, current therapies fail in achieving predictable and consistent regeneration. Cell and molecular biology research in periodontal regeneration hold great promise in providing improved understanding of this complex phenomenon and direct us towards new possibilities of future clinical application. This paper reviews both the cells and extracellular matrix of the periodontal ligament in addition to the cell-to-matrix and cell-to-cell interaction involved in periodontal regeneration. Results of recent studies have suggested that periodontal regeneration recapitulates the process of morphogenesis, histogenesis, and cytodifferentiation, as well as cell field migration that occurs during development of the periodontium. A small population of purported periodontal stem cells is believed to be responsible for maintaining homeostasis in the periodontal ligament. This cell, which may have its origin in late periodontal mesenchyme of the dental papilla, is advocated as a tripotential cell capable of differentiating into cementoblast, osteoblast, and periodontal fibroblast. The clinical implication of advances made in cell and molecular biology research in periodontal regeneration may include future use of biomolecules in periodontal regeneration may include future use of biomolecules to improve the regenerative healing process and use of bioactive degradable membrane barriers in guided tissue regeneration as well as seeding of periodontal stem cells into periodontal defects. If the current trend continues, clinicians can look forward to seeing periodontal wound healing being substantially enhanced to achieve predictable periodontal regeneration.