Renal clearance of quantum dots
Renal clearance of quantum dots
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DOI：
10.1038/nbt1340
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发表时间：
2007-10-01
影响因子：
46.9
通讯作者：
Frangioni, John V.
中科院分区：
文献类型：
--
作者：
Choi, Hak Soo;Liu, Wenhao;Frangioni, John V.
纳米技术领域在人类疾病的诊断和治疗方面具有巨大的潜力。然而，大多数纳米粒子的大小和电荷使其无法作为完整的纳米粒子从体内有效清除。如果没有这种清除或者它们没有生物降解为对生物无害的成分，毒性可能会增强，放射成像也会受阻。我们以在啮齿动物体内静脉注射量子点作为模型系统，精确地确定了无机的含金属纳米粒子进行肾滤过和尿液排泄的条件。两性离子或中性有机涂层可防止血清蛋白吸附，否则血清蛋白会使流体动力学直径增加>15纳米，并阻碍肾脏排泄。最终的流体动力学直径……
The field of nanotechnology holds great promise for the diagnosis and treatment of human disease. However, the size and charge of most nanoparticles preclude their efficient clearance from the body as intact nanoparticles. Without such clearance or their biodegradation into biologically benign components, toxicity is potentially amplified and radiological imaging is hindered. Using intravenously administered quantum dots in rodents as a model system, we have precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles. Zwitterionic or neutral organic coatings prevented adsorption of serum proteins, which otherwise increased hydrodynamic diameter by > 15 nm and prevented renal excretion. A final hydrodynamic diameter