Circulating MicroRNAs Biomarkers or Mediators of Cardiovascular Diseases?
Circulating MicroRNAs Biomarkers or Mediators of Cardiovascular Diseases?
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DOI：
10.1161/atvbaha.111.226696
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发表时间：
2011-11-01
影响因子：
8.7
通讯作者：
Dimmeler, Stefanie
中科院分区：
文献类型：
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作者：
Fichtlscherer, Stephan;Zeiher, Andreas M.;Dimmeler, Stefanie
MicroRNAs(MiRs)是一种小的、非编码的RNA，通过抑制蛋白质翻译或诱导靶基因的不稳定来在转录后控制基因的表达。最近的研究表明，除了细胞内的功能外，miRs还可以由细胞输出或释放，并以非常稳定的形式与血液循环。循环MIR的发现为将循环MIR模式用作心血管疾病的生物标记物开辟了有趣的可能性。急性心肌梗死后发生的心脏损伤增加了几种心肌来源的miR(如miR-1、miR-133、miR-499、miR-208)的循环水平，而冠心病或糖尿病患者表现出内皮丰富的miR水平降低，如miR-126。本文综述了目前有关循环MIR作为心血管疾病诊断或预后生物标志物的作用的临床和实验研究。此外，还讨论了MIR的释放机制以及它们作为远程通信者的假定功能。(动脉血栓血管生物)2011；31：2383-2390。)
MicroRNAs (miRs) are small, noncoding RNAs that posttranscriptionally control gene expression by inhibiting protein translation or inducing target mRNA destabilization. Besides their intracellular function, recent studies demonstrate that miRs can be exported or released by cells and circulate with the blood in a remarkably stable form. The discovery of circulating miRs opens up intriguing possibilities to use the circulating miR patterns as biomarker for cardiovascular diseases. Cardiac injury as it occurs after acute myocardial infarction increases the circulating levels of several myocardial-derived miRs (eg, miR-1, miR-133, miR-499, miR-208), whereas patients with coronary artery disease or diabetes showed reduced levels of endothelial-enriched miRs, such as miR-126. This review article summarizes the current clinical and experimental studies addressing the role of circulating miRs as a diagnostic or prognostic biomarker in cardiovascular disease. In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed. (Arterioscler Thromb Vasc Biol. 2011;31:2383-2390.)