A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes.
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DOI：
10.7554/elife.69514
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发表时间：
2021-11-25
期刊：
影响因子：
7.7
通讯作者：
Polley DB
中科院分区：
文献类型：
--
作者：
Robert B;Kimchi EY;Watanabe Y;Chakoma T;Jing M;Li Y;Polley DB
基底前脑胆碱能神经元 (BFCN) 投射到整个皮层，以调节唤醒、刺激显着性、可塑性和学习。尽管基底前脑经常被视为整体结构，但其沿其头尾轴具有明显的连接性，这可能会导致 BFCN 处理的区域差异。在这里，我们对小鼠进行了为期 1 个月的可变强化学习，同时对头侧和尾侧 BFCN 进行了大量钙成像。两个区域的 BFCN 对无条件视觉刺激和预期奖励的反应同样较弱。对角带水平肢的喙部 BFCN 对奖励遗漏反应更灵敏，行为结果分类更准确，并且更密切地跟踪瞳孔索引的全局大脑状态的波动。苍白球和无名质中的尾部 BFCN 对无条件听觉刺激、口面部运动、厌恶强化更敏感，并且对惩罚预测线索表现出强大的联想可塑性。这些结果确定了一种功能拓扑，可以使广播到下游大脑区域的胆碱能调节信号多样化。
Basal forebrain cholinergic neurons (BFCNs) project throughout the cortex to regulate arousal, stimulus salience, plasticity, and learning. Although often treated as a monolithic structure, the basal forebrain features distinct connectivity along its rostrocaudal axis that could impart regional differences in BFCN processing. Here, we performed simultaneous bulk calcium imaging from rostral and caudal BFCNs over a 1-month period of variable reinforcement learning in mice. BFCNs in both regions showed equivalently weak responses to unconditioned visual stimuli and anticipated rewards. Rostral BFCNs in the horizontal limb of the diagonal band were more responsive to reward omission, more accurately classified behavioral outcomes, and more closely tracked fluctuations in pupil-indexed global brain state. Caudal tail BFCNs in globus pallidus and substantia innominata were more responsive to unconditioned auditory stimuli, orofacial movements, aversive reinforcement, and showed robust associative plasticity for punishment-predicting cues. These results identify a functional topography that diversifies cholinergic modulatory signals broadcast to downstream brain regions.