Inhibition of liver metastases of M 5076 tumor by liposome-entrapped adriamycin.
Inhibition of liver metastases of M 5076 tumor by liposome-entrapped adriamycin.
复制标题
脂质体包埋的阿霉素抑制 M 5076 肿瘤的肝转移。
DOI：
10.1089/cdd.1983.1.43
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Vail,WJ
中科院分区：
文献类型：
--
作者：
Mayhew,E;Rustum,Y;Vail,WJ
在正常小鼠和携带 M 5076 小鼠肿瘤（静脉注射后转移至肝脏）的小鼠中评估了游离阿霉素 (AM) 和标准化脂质体包埋的 AM (AM-MLV) 的毒性和治疗效果。和 s.c.肿瘤细胞悬浮液移植。通过将药物封装在脂质体中可以减少 AM 的急性和慢性毒性。数据表明，在游离 AM (10 mg/kg) 和 AM-MLV (>20 mg/kg) 的大致等毒剂量下，静脉移植小鼠的存活时间增加。肿瘤细胞的比率分别为25%和100%。此外，只有在 AM-MLV 治疗的小鼠中才观察到长期存活。相比之下，在皮下移植小鼠中，AM-MLV 与游离 AM 同等有效。与肿瘤细胞悬浮液。然而，对于皮下移植小鼠的肝转移，AM-MLV 比游离 AM 更有效。肿瘤，表明对同一动物不同部位生长的同一肿瘤类型的抗肿瘤活性存在差异。
The toxicity and therapeutic efficacy of free adriamycin (AM) and AM entrapped in standardized liposomes (AM-MLV) were evaluated in normal mice and in mice bearing M 5076 murine tumor, which metastasizes to the liver after i.v. and s.c. transplants of tumor cell suspensions. Acute and chronic toxicity to AM could be reduced by drug encapsulation in liposomes. The data indicated that at approximately equitoxic doses of free AM (10 mg/kg) and AM-MLV (>20 mg/kg), the increase in survival times of mice transplanted i.v. with tumor cells were 25% and 100%, respectively. Furthermore, only in the AM-MLV-treated mice were long-term survivors observed. In contrast AM-MLV were equally effective as free AM in mice transplanted s.c. with tumor cell suspensions. AM-MLV, however, were more effective than free AM against liver metastases in mice bearing s.c. tumor, indicating differential antitumor activities against the same tumor type growing at different locations in the same animals.