Dopaminergic Terminals in the Rat Cortex
Dopaminergic Terminals in the Rat Cortex
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大鼠皮质中的多巴胺能终端
DOI：
10.1126/science.182.4111.499
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发表时间：
1973
期刊：
影响因子：
56.9
通讯作者：
J. Glowinski
中科院分区：
文献类型：
--
作者：
A. Thierry;G. Blanc;A. Sobel;L. Stinus;J. Glowinski
双侧小脑上蒂侧注射6-羟多巴胺破坏了去甲肾上腺素上行通路，完全破坏了大鼠皮层突触体和切片中L-[3H]酪氨酸体外合成[3H]去甲肾上腺素。然而，在病变动物的两种皮质制剂中，仍可观察到正常的[3H]多巴胺合成。这些结果为大鼠皮层中存在独立于去甲肾上腺素能终端的多巴胺能终端提供了第一个生化支持。
The destruction of ascending noradreniergic pathways by bilateral microinjections of 6-hydroxydopamnine made laterally to the pedunculus cerebellaris superior completely abolished the in vitro synthesis of [3H]norepinephrine from L-[3H]tyrosine in slices and in synaptosomes of the rat cortex. However, normal [3H]dopamine synthesis could still be observed in both cortical preparations from animals with lesions. These results provide the first biochemical support for the existence of dopaminergic terminals independent of noradrenergic terminals in the rat cortex.