Multiple or Single Duplication Events Leading to the Emergence of a Novel Genotype of Respiratory Syncytial Virus.
Multiple or Single Duplication Events Leading to the Emergence of a Novel Genotype of Respiratory Syncytial Virus.
复制标题
多个或单个复制事件导致呼吸道合胞病毒新基因型的出现。
DOI：
10.1093/infdis/jiy154
复制
发表时间：
2018
影响因子：
6.4
通讯作者：
Furuse Y.
中科院分区：
文献类型：
--
作者：
Hiromi Takaki;Haruko Sato;Riho Kurata;Hirokazu Hikono;Takahiro Hiono;Hiroshi Kida;Misako Matsumoto;Takehiko Saito;Tsukasa Seya;Furuse Y.
应注意的是，NPNP病毒（RSVA/智人/JOR/A0215/2011）是通过独立的复制事件由NP病毒产生的，其可以与导致YPYP和YLYL病毒出现的复制事件清楚地区分开。虽然NPNP病毒具有相同的复制位点，但我们认为它不应被归类为ON 1，而应被归类为GA 2基因型。我们同意72个核苷酸的重复位点是ON 1病毒的一个特征;然而，重复位点的存在并不能决定基因型。每种基因型包含一组遗传距离很近的单个病毒; NPNP病毒不具有ON 1基因型，因为它与NL、NP、YP和YL病毒的距离很近（均具有GA 2基因型），并与YPYP和YLYL病毒有明显区别（图1，右图）。虽然我们不同意存在多次重复事件导致ON 1基因型出现3次独立的理论，阐明G基因重复发生的机制以及为什么G基因重复不会减少的重要性。除了导致ON 1基因型出现的重复事件外，NPNP病毒还由独立的重复事件产生。在RSV亚组B和副粘病毒科的其他成员（例如，人偏肺病毒）中也报告了部分G基因的重复[5-7]。需要进一步的研究来阐明这种重复的进化、病毒学和临床意义。
It should be noted that the NPNP virus (RSVA/Homo sapiens/JOR/A0215/2011) was generated from NP viruses by an independent duplication event, which can be clearly distinguished from the duplication event leading to the emergence of YPYP and YLYL viruses. Although the NPNP virus possesses the same duplication site, we suggest that it should not be classified as the ON1 but as the GA2 genotype. We agree that the 72-nucleotide duplication site is a characteristic feature of the ON1 virus; however, the presence of the duplication site is not definitive of the genotype. Each genotype encompasses a group of individual viruses within a close genetic distance; the NPNP virus does not have the ON1 genotype, given its close distance to NL, NP, YP, and YL viruses (all have the GA2 genotype) and a clear distinction from YPYP and YLYL viruses (Figure 1, right panel).Although we do not agree with the theory that there were multiple duplication events leading to 3 independent emergences of the ON1 genotype, importance to elucidate the mechanismsunderlying how and why the duplicationoccurred in the G gene will notdecrease. In addition to the duplication event that resulted in the emergence of the ON1 genotype, the NPNP virus was generated by an independent duplication event. The duplication of a part of the G gene has also been reported in the RSV subgroup B and in other members of the Paramyxoviridae family (eg, human metapneumovirus)[5–7]. Further study is needed to elucidate the evolutionary, virological, and clinical significance of this duplication.