Information Phage Therapy Research Should Report.
Information Phage Therapy Research Should Report.
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DOI：
10.3390/ph10020043
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发表时间：
2017-04-30
期刊：
影响因子：
--
通讯作者：
Abedon ST
中科院分区：
文献类型：
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作者：
Abedon ST
噬菌体或噬菌体是感染细菌的病毒。很大一部分噬菌体具有杀菌作用，因此，近一百年来，它们一直被用作医药内外的抗菌剂。在临床上，这些应用被称为噬菌体或噬菌体治疗。另外，特别是在环境处理中，这种做法可以被描述为噬菌体介导的细菌生物防治。尽管噬菌体治疗的历史涉及大量的临床实验，但目前的标准以及药物法规都非常重视临床前方法，即动物实验。因此，重要的是临床前实验不仅要保持高标准，而且要以一种提高临床应用转化的方式进行报告。在这里，我解决了后一个问题，即临床前和临床实验报告的优化。为此，我提供了一份相关信息和数据清单，在我看来，噬菌体治疗实验应该在出版物中呈现，以及最佳实践提示。目标是提高读者从噬菌体治疗研究报告中获得相关信息的能力，使其他研究人员有更大的潜力重复或扩展研究结果，简化从临床前到临床开发的过渡，或者简单地改进噬菌体治疗实验。目标不仅仅是作者，还有评论者、其他批判性读者、评论作者，也许还有指导方针或政策的制定者。虽然强调治疗，但许多观点更适用于噬菌体介导的细菌生物防治。
Bacteriophages, or phages, are viruses which infect bacteria. A large subset of phages infect bactericidally and, consequently, for nearly one hundred years have been employed as antibacterial agents both within and outside of medicine. Clinically these applications are described as phage or bacteriophage therapy. Alternatively, and especially in the treatment of environments, this practice instead may be described as a phage-mediated biocontrol of bacteria. Though the history of phage therapy has involved substantial clinical experimentation, current standards along with drug regulations have placed a premium on preclinical approaches, i.e., animal experiments. As such, it is important for preclinical experiments not only to be held to high standards but also to be reported in a manner which improves translation to clinical utility. Here I address this latter issue, that of optimization of reporting of preclinical as well as clinical experiments. I do this by providing a list of pertinent information and data which, in my opinion, phage therapy experiments ought to present in publications, along with tips for best practices. The goal is to improve the ability of readers to gain relevant information from reports on phage therapy research, to allow other researchers greater potential to repeat or extend findings, to ease transitions from preclinical to clinical development, and otherwise simply to improve phage therapy experiments. Targeted are not just authors but also reviewers, other critical readers, writers of commentaries, and, perhaps, formulators of guidelines or policy. Though emphasizing therapy, many points are applicable to phage-mediated biocontrol of bacteria more generally.