THE RELATIONSHIP BETWEEN THE MYDRIATIC ACTION OF EPHEDRINE AND THE COLOUR OF THE IRIS*
THE RELATIONSHIP BETWEEN THE MYDRIATIC ACTION OF EPHEDRINE AND THE COLOUR OF THE IRIS*
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麻黄碱的散瞳作用与虹膜颜色之间的关系*
DOI：
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发表时间：
1965
影响因子：
4.1
通讯作者：
M. Rand
中科院分区：
文献类型：
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作者：
H. Obianwu;M. Rand
前言它是众所周知的执业眼科医生，麻黄碱是不太有效的散瞳剂的主题深颜色的虹膜比那些与轻虹膜。这一观察结果首先由霍华德和李（1927年）报道，他们指出，具有浅色虹膜的高加索人和具有深色虹膜的中国人之间存在明显差异，前者对较小的剂量有反应，并产生较大的瞳孔放大，在同等剂量下发展得更快。Chen和Poth（1929 a，B）观察到，麻黄碱在扩张非裔和华裔美国人瞳孔方面的活性远低于白色美国人。巴比和史密斯（Barbee and Smith，1957）在美国黑人身上证实了这些发现，并发现在白色美国人中，那些拥有淡褐色、棕色或黑色虹膜的人比那些拥有蓝色、灰色或绿色虹膜的人反应更弱。然而，Sattler（1927）报告说，他在欧洲人和一名黑人受试者中观察到棕色、绿色或蓝色虹膜对麻黄碱的散瞳反应没有差异。我们无法找到关于麻黄碱对不同颜色虹膜和不同种族受试者的散瞳作用的任何其他报告，因此我们利用这个机会对居住在大学宿舍的非洲、印度、中国和欧洲学生进行了观察。
Introduction IT is well known to practising ophthalmologists that ephedrine is less effective as a mydriatic in subjects with deeply coloured irides than in those with light irides. This observation was first reported by Howard and Lee (1927), who stated that there was a distinct difference between Caucasians with light coloured irides and Chinese with dark irides, the former responding to smaller doses, and giving a larger mydriasis which developed more rapidly to equal doses. Chen and Poth (1929a, b) observed that ephedrine was considerably less active in dilating the pupils in Americans of African and Chinese descent than in white Americans. Barbee and Smith (1957) confirmed these findings with American negroes and found that among white Americans, those with hazel, brown, or black irides were less responsive than those with blue, grey, or green irides. However, Sattler (1927) reported that he saw no difference in the mydriatic response of brown, green, or blue irides to ephedrine in Europeans and in one negro subject. We were not able to find any other reports on the mydriatic actions of ephedrine in subjects with different coloured irides and from different ethnic groups, so we took the opportunity to make observations in African, Indian, Chinese, and European students living in a university hall of residence.