Compartmental analysis of zinc kinetics in mature male rats
Compartmental analysis of zinc kinetics in mature male rats
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DOI：
10.1152/ajpregu.1997.273.3.r1117
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发表时间：
1997-09-01
影响因子：
2.8
通讯作者：
Wastney, ME
中科院分区：
文献类型：
--
作者：
House, WA;Wastney, ME
建立了成年雄性大鼠锌动力学房室模型。该模型是基于锌和放射性同位素锌测定的样品中的血浆，骨骼肌，肾脏，睾丸，脾脏，骨，肠段收集在不同的时间，锌-65静脉注射后长达4天。同时测定了锌的摄入量、尿和粪中锌和锌-65的排泄量以及锌-65的全身蓄积量。用于开发模型的其他数据包括未采样组织中锌浓度和锌动力学的已发表信息。在该模型中，肠道由五个隔室表示。血浆、脾脏、肾脏和睾丸分别用单个隔室表示。相反，两个隔室分别用于代表肝脏、骨骼、骨骼肌、皮肤和红细胞中的可交换锌。本模型扩展了早期的锌动力学模型，描述了锌在全身的分布，并可能提供一种手段来评估病理生理条件或饮食极端对锌代谢的影响。
A compartmental model of zinc kinetics in mature male rats was developed. The model was based on zinc and radioisotopic zinc measured in samples of plasma, skeletal muscle, kidneys, testes, spleen, bone, and intestinal segments collected at various times for up to 4 days after Zn-65 was injected intravenously. Zinc intake, excretion of zinc and Zn-65 in urine and feces, and the whole body retention of Zn-65 were also determined. Other data used to develop the model included published information on zinc concentration and zinc kinetics in tissues that were not sampled. In the model, the intestinal tract was represented by five compartments. Plasma, spleen, kidneys, and testes were each represented by an individual compartment. In contrast, two compartments each were used to represent exchangeable zinc in liver, bone, skeletal muscle, skin, and red blood cells. The present model extends earlier models of zinc kinetics, describes the distribution of zinc in the whole body, and may provide a means to evaluate the influence of either pathophysiological conditions or dietary extremes on the metabolism of zinc.