SURFACE-INDUCED DISSOCIATION OF MOLECULAR-IONS IN A QUADRUPOLE ION TRAP MASS-SPECTROMETER
SURFACE-INDUCED DISSOCIATION OF MOLECULAR-IONS IN A QUADRUPOLE ION TRAP MASS-SPECTROMETER
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DOI：
10.1016/1044-0305(91)80036-7
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发表时间：
1991-11-01
影响因子：
3.2
通讯作者：
COOKS, RG
中科院分区：
文献类型：
--
作者：
LAMMERT, SA;COOKS, RG
报道了一种利用表面诱导解离激活四极杆离子阱质谱仪中储存的离子的方法。 该方法采用短（< 5 μ s）、快速上升（< 20 ns上升时间）、高压直流（dc）脉冲，该脉冲被施加到标准Paul型四极离子阱的端盖。 这与通常用于共振激发和解离阱中的离子的交流（ac）信号的应用相反。 直流脉冲的作用是使离子在径向上迅速变得不稳定，随后与环形电极碰撞。 在这种碰撞中获得了足够的内能，导致相对难处理的分子离子如芘和苯的高能碎裂。 柠檬烯的离解被用来证明，高能量需求过程中增加的相对重要性，在直流脉冲实验中相比，通常的共振激发方法，用于引起激活。 使用传统的质量选择性不稳定性扫描模式将碎片扫描出离子阱。 阱中离子运动的模拟提供了证据，表明表面碰撞发生在几十到几百电子伏的动能范围内。 实验还表明，碎片离子的产生是敏感的主射频驱动电压的相位在直流启动时的点。
A method is reported by which surface-induced dissociation is used to activate ions stored in a quadrupole ion trap mass spectrometer. The method employs a short (< 5-mu-s), fast-rising (< 20-ns rise time), high voltage direct current (dc) pulse, which is applied to the endcaps of a standard Paul-type quadrupole ion trap. This is in contrast to the application of an alternating current (ac) signal normally used to resonantly excite and dissociate ions in the trap. The effect of the dc pulse is to cause the ions rapidly to become unstable in the radial direction and subsequently to collide with the ring electrode. Sufficient internal energy is acquired in this collision to cause high energy fragmentations of relatively intractable molecular ions such as pyrene and benzene. The dissociations of limonene are used to demonstrate that high energy demand processes increase in relative importance in the dc pulse experiment compared with the usual resonance excitation method used to cause activation. The fragments are scanned out of the ion trap using the conventional mass-selective instability scan mode. Simulations of ion motion in the trap provide evidence that surface collisions occur at kinetic energies in the range of tens to several hundred electronvolts. The experiments also demonstrate that production of fragment ions is sensitive to the phase of the main radiofrequency drive voltage at the point when the dc is initiated.