CEREBROVASCULAR COMPLICATIONS OF MUCINOUS CANCERS
CEREBROVASCULAR COMPLICATIONS OF MUCINOUS CANCERS
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DOI：
10.1212/wnl.39.4.522
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发表时间：
1989-04-01
期刊：
影响因子：
9.9
通讯作者：
THOMAS, C
中科院分区：
文献类型：
--
作者：
AMICO, L;CAPLAN, LR;THOMAS, C
6例粘液癌患者（2例结肠癌、2例胰腺癌和2例肺源性癌）的尸检证据显示，全身、颅外和颅内的大、小动脉和静脉血栓形成，以及多发性脑梗死和小血管闭塞。在显微镜检查中，我们发现大脑内有小梗塞和出血，血管、巨噬细胞和梗塞区域内有粘蛋白。临床表现包括中风和脑病。产生粘蛋白的癌症可能与引起广泛闭塞性血管疾病的凝血病有关。
Six patients with mucinous cancer (2 colonic, 2 pancreatic, and 2 pulmonary origin) had necropsy evidence of thrombosis of large and small systemic, extracranial, and intracranial arteries and veins, and multiple cerebral infarcts and small hemorrhages. On microscopic examination, we found small infarcts and hemorrhages within the brain and mucin within vessels, macrophages, and in areas of infarction. The clinical picture included strokes and encephalopathy. Mucin-producing cancers can be associated with a coagulopathy that causes extensive occlusive vascular disease.