Toward a further elucidation: Role of vertebral artery hypoplasia in acute ischemic stroke
Toward a further elucidation: Role of vertebral artery hypoplasia in acute ischemic stroke
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DOI：
10.1159/000093868
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Yang, Ching-Yih
中科院分区：
文献类型：
--
作者：
Chuang, Yu-Ming;Huang, Yuarn-Chung;Yang, Ching-Yih
背景和目的：先天性椎动脉发育不全是一种罕见的后循环胚胎变异。根据尸检和血管造影片，这种先天性变异的频率报告为2-6%。本研究的目的是阐明VA发育不全在急性缺血性卒中中的作用。方法：我们检查了191例急性缺血性卒中患者（年龄55.8 ± 14.0岁）。确定吐司亚型。所有患者均行颈部磁共振血管造影。在缺血性卒中发作后72小时内，对双侧VA进行了多普勒研究，记录横突间（V2）段的流速和血管直径。测量每例受试者的VA净流量。结果：单侧先天性VA发育不良的总发生率为11.51%，尤其是脑干/小脑梗死病例的发生率更高。其中，VA发育不良的受试者在病因学上以“大动脉粥样硬化”亚型为主，在地形学上以同侧后循环梗死为主。结论：根据我们的研究结果，VA发育不良似乎是急性缺血性卒中的一个促成因素，尤其是在后循环区域。版权所有（c）2006 S. Karger AG，巴塞尔。
Background and Purpose: Congenital vertebral artery (VA) hypoplasia is an uncommon embryonic variation of posterior circulation. The frequency of this congenital variation was reported to be 2-6% from autopsy and angiograms. The aim of our study was to elucidate the role of VA hypoplasia in acute ischemic stroke. Method: We examined 191 acute ischemic stroke patients (age 55.8 +/- 14.0 years). TOAST subtypes were determined. A cervical magnetic resonance angiogram was performed in every patient. A duplex study of bilateral VA with flow velocities and vessel diameter recording in the intertransverse (V2) segment was performed within 72 h after onset of ischemic stroke. The net VA flow volume was measured in each subject. Result:The overall incidence of a unilateral congenital hypoplastic VA was 11.51%, which was statistically higher especially in cases of brainstem/cerebellar infarction. Of these, subjects with VA hypoplasia had an etiological preponderance of the 'large-artery atherosclerosis' subtype and a topographic preponderance of ipsilateral posterior circulation infarction. Conclusions: Based on our results, VA hypoplasia seemed a contributing factor of acute ischemic stroke, especially in posterior circulation territories. Copyright (c) 2006 S. Karger AG, Basel.