Platelet activation in patients with psoriasis: Increased plasma levels of platelet-derived microparticles and soluble P-selectin
Platelet activation in patients with psoriasis: Increased plasma levels of platelet-derived microparticles and soluble P-selectin
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DOI：
10.1016/j.jaad.2009.06.053
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发表时间：
2010-04-01
影响因子：
13.8
通讯作者：
Kishimoto, Saburo
中科院分区：
文献类型：
--
作者：
Tamagawa-Mineoka, Risa;Katoh, Norito;Kishimoto, Saburo
背景：最近已经确定血小板除了在止血和血栓形成中起主要作用外，还在增加炎症中起重要作用。据报道，银屑病患者血管闭塞性疾病的发病率增加，银屑病的发病机制可能与血小板活化有关。目的：本研究的目的是通过调查银屑病患者血小板活化标志物的水平以及市场水平与银屑病严重程度评分之间的关系，建立血小板活化与银屑病活动性之间的更清晰的解释。方法：采用酶联免疫吸附法测定21例银屑病患者血浆血小板源性微粒（PDMPs）和可溶性p选择素水平，作为血小板活化指标。探讨血小板活化标志物与银屑病面积及严重程度指数评分的关系。结果：银屑病患者血浆PDMPs和可溶性p选择素水平明显高于健康对照组。PDMPs水平与银屑病面积和严重程度指数评分有显著相关性，临床改善后血浆PDMPs和可溶性p选择素水平升高明显降低。局限性：被评估的人数相对较少。结论：我们的研究结果表明，血小板在银屑病患者中被激活，特别是在疾病广泛的患者中，血小板活化与银屑病的活性密切相关。血浆PDMPs水平可能是银屑病严重程度的有用指标。[j] .中华皮肤科杂志，2010;62:621- 626。
Background: It has recently been established that platelets have an important role in increasing inflammation, in addition to their main role in hemostasis and thrombosis. An increased incidence of occlusive vascular disease has been reported in patients with psoriasis and the pathomechanism of psoriasis may involve platelet activation.Objective: The goal of the study was to establish a clearer explanation of the association between platelet activation and psoriasis activity by investigating the levels of markers of platelet activation in patients with psoriasis and examining the relationship between the market levels and a severity score for psoriasis.Methods: Plasma levels of platelet-derived microparticles (PDMPs) and soluble P-selectin were measured by enzyme-linked immunosorbent assay as markers of platelet activation in 21 patients with psoriasis and 22 healthy control subjects. The relationships between the platelet activation markers and the Psoriasis Area and Severity Index score were investigated.Results: Plasma PDMPs and soluble P-selectin levels were markedly higher in patients with psoriasis compared with those in healthy control subjects. There was a significant correlation between the PDMPs levels and the Psoriasis Area and Severity index score, and the increased plasma PDMPs and soluble P-selectin levels were markedly reduced after clinical improvement occurred.Limitations: The number of people evaluated was relatively small.Conclusions: Our results Show that blood platelets are activated in patients with psoriasis, especially in those with extensive disease, and Suggest a close association between platelet activation and psoriasis activity. Plasma PDMPs level may be a useful indicator of the severity of psoriasis. Q Am Acad Dermatol 2010;62:621-6.)