Attention deficit hyperactivity disorder and autism spectrum disorder symptoms in school-age children born very preterm
Attention deficit hyperactivity disorder and autism spectrum disorder symptoms in school-age children born very preterm
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DOI：
10.1016/j.ridd.2018.01.001
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发表时间：
2018-03-01
影响因子：
3.1
通讯作者：
Oosterlaan, Jaap
中科院分区：
文献类型：
--
作者：
Broring, Tinka;Oostrom, Kim J.;Oosterlaan, Jaap
背景：非常早产（VP）儿童面临广泛的神经发育后遗症，包括行为问题。目的：探讨学龄前极早产儿注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）症状的患病率、普遍性和共发病情况。方法：采用问卷调查和诊断性访谈资料，将57名vp儿童（平均年龄9.2岁）的家长和老师报告的ADHD和ASD症状与57名性别和年龄匹配的足月儿童进行t检验比较。班级内相关系数量化家长教师协议。相关分析调查ADHD/ASD症状的共发情况。ADHD/ASD测量数据采用主成分分析进行汇总。回归分析调查了围产期危险因素、性别和社会经济地位对ADHD/ASD症状的影响。结果：副总裁儿童在家长和老师报告的注意力问题、社交障碍和沟通技巧方面表现出更高的水平。家长和老师报告的ADHD和ASD症状基本一致，表明观察到的困难普遍存在。发现ADHD和ASD症状在vp儿童中共现。较低胎龄与较高的ADHD和ASD症状水平相关，男性与较高的ADHD症状水平相关，较低的社会地位与较高的ASD症状水平相关。结论：学龄期vp儿童表现出较高程度的ADHD和ASD症状，特别是注意、社交和沟通困难。建议在后续护理中对这些问题进行常规筛查。
Background: Very preterm (VP) children face a broad range of neurodevelopmental sequelae, including behavioral problems.Aim: To investigate prevalence, pervasiveness and co-occurrence of symptoms of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) in school-age children born very preterm.Methods: Using questionnaire and diagnostic interview data, parent and teacher reported symptoms of ADHD and ASD of 57 VP-children (mean age = 9.2 years) were compared with 57 gender and age matched full-term children using t-tests. Intra-class correlation coefficients quantified parent-teacher agreement. Correlation analysis investigated co-occurrence of ADHD/ASD symptoms. ADHD/ASD measures were aggregated using principal component analysis. Regression analyses investigated the contribution of perinatal risk factors, sex and SES to ADHD/ASD symptoms.Results: VP-children showed higher levels of parent and teacher reported attention problems, social impairment and compromised communication skills. Fair to strong agreement was found between parent and teacher reported ADHD and ASD symptoms, indicating pervasiveness of observed difficulties. Co-occurrence of ADHD and ASD symptoms in VP-children was found. Lower gestational age was associated with higher ADHD and ASD symptom levels, male sex with higher ADHD symptom levels and lower SES with higher ASD symptom levels.Conclusion: School-age VP-children show higher levels of ADHD and ASD symptoms, and attention, socialization and communication difficulties in particular. Routinely screening for these problems is recommended in follow-up care.